Matches in SemOpenAlex for { <https://semopenalex.org/work/W2996985678> ?p ?o ?g. }
- W2996985678 endingPage "334" @default.
- W2996985678 startingPage "327" @default.
- W2996985678 abstract "The need for in situ accurate identification of tumor assisted real-time image-guided surgical resection calls for new near-infrared fluorescence agents with high tumor-sensitivity and excellent biocompatibility. Here, an albumin-conjugate nanoparticle system HSA-Er-RI-Cl was designed, synthesized, and applied in cancer imaging, which simultaneously achieved the EPR effect, hypoxia-targeting, and EGFR-targeting property. Our novel nanoprobe is composed of human serum albumin (HSA) and double-targeting small molecule conjugate (Er-RI-Cl): a hypoxia-targeting heptamethine carbocyanine dye (RI-Cl) conjugated with a clinic anti-EGFR antagonist (Erlotinib) by covalent bonding. This conjugate could bind to albumin proteins, forming albumin-conjugate complexes, and those complexes self-assemble into particles with diameters of approximately 100 nm in the aqueous solution. The tumor hypoxia and EGFR targeting specificity of HSA-Er-RI-Cl was, respectively, evaluated in vitro and in vivo. Using murine xenograft subcutaneous and brain metastatic tumor models, we demonstrated that HSA-Er-RI-Cl is a highly potent tumor-targeting NIR agent for noninvasive imaging with remarkable tumor localization and excellent pharmacokinetic properties." @default.
- W2996985678 created "2020-01-10" @default.
- W2996985678 creator A5002460619 @default.
- W2996985678 creator A5021083697 @default.
- W2996985678 creator A5051260674 @default.
- W2996985678 creator A5052689516 @default.
- W2996985678 creator A5060822341 @default.
- W2996985678 creator A5080150992 @default.
- W2996985678 creator A5083702992 @default.
- W2996985678 creator A5084533462 @default.
- W2996985678 date "2019-12-24" @default.
- W2996985678 modified "2023-10-13" @default.
- W2996985678 title "A Self-Assembled “Albumin–Conjugate” Nanoprobe for Near Infrared Optical Imaging of Subcutaneous and Metastatic Tumors" @default.
- W2996985678 cites W1966050112 @default.
- W2996985678 cites W1968889670 @default.
- W2996985678 cites W1969545696 @default.
- W2996985678 cites W1977507206 @default.
- W2996985678 cites W2000408758 @default.
- W2996985678 cites W2005204942 @default.
- W2996985678 cites W2021149350 @default.
- W2996985678 cites W2034136876 @default.
- W2996985678 cites W2036456322 @default.
- W2996985678 cites W2044884111 @default.
- W2996985678 cites W2057896630 @default.
- W2996985678 cites W2082511916 @default.
- W2996985678 cites W2084746469 @default.
- W2996985678 cites W2091320745 @default.
- W2996985678 cites W2106235642 @default.
- W2996985678 cites W2119096960 @default.
- W2996985678 cites W2134967712 @default.
- W2996985678 cites W2135575642 @default.
- W2996985678 cites W2142247783 @default.
- W2996985678 cites W2148060280 @default.
- W2996985678 cites W2150199541 @default.
- W2996985678 cites W2151196497 @default.
- W2996985678 cites W2265134273 @default.
- W2996985678 cites W2327988534 @default.
- W2996985678 cites W2335752216 @default.
- W2996985678 cites W2343811944 @default.
- W2996985678 cites W2508777905 @default.
- W2996985678 cites W2608695549 @default.
- W2996985678 cites W2762554530 @default.
- W2996985678 cites W2810142842 @default.
- W2996985678 cites W2903084459 @default.
- W2996985678 cites W2908439673 @default.
- W2996985678 cites W4248585778 @default.
- W2996985678 doi "https://doi.org/10.1021/acsabm.9b00839" @default.
- W2996985678 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35019449" @default.
- W2996985678 hasPublicationYear "2019" @default.
- W2996985678 type Work @default.
- W2996985678 sameAs 2996985678 @default.
- W2996985678 citedByCount "2" @default.
- W2996985678 countsByYear W29969856782020 @default.
- W2996985678 countsByYear W29969856782021 @default.
- W2996985678 crossrefType "journal-article" @default.
- W2996985678 hasAuthorship W2996985678A5002460619 @default.
- W2996985678 hasAuthorship W2996985678A5021083697 @default.
- W2996985678 hasAuthorship W2996985678A5051260674 @default.
- W2996985678 hasAuthorship W2996985678A5052689516 @default.
- W2996985678 hasAuthorship W2996985678A5060822341 @default.
- W2996985678 hasAuthorship W2996985678A5080150992 @default.
- W2996985678 hasAuthorship W2996985678A5083702992 @default.
- W2996985678 hasAuthorship W2996985678A5084533462 @default.
- W2996985678 hasBestOaLocation W29969856781 @default.
- W2996985678 hasConcept C112613896 @default.
- W2996985678 hasConcept C12554922 @default.
- W2996985678 hasConcept C126322002 @default.
- W2996985678 hasConcept C134306372 @default.
- W2996985678 hasConcept C150903083 @default.
- W2996985678 hasConcept C155672457 @default.
- W2996985678 hasConcept C16387964 @default.
- W2996985678 hasConcept C171250308 @default.
- W2996985678 hasConcept C178790620 @default.
- W2996985678 hasConcept C185592680 @default.
- W2996985678 hasConcept C192562407 @default.
- W2996985678 hasConcept C197336794 @default.
- W2996985678 hasConcept C207001950 @default.
- W2996985678 hasConcept C2776125364 @default.
- W2996985678 hasConcept C2778172261 @default.
- W2996985678 hasConcept C2778597219 @default.
- W2996985678 hasConcept C2779081379 @default.
- W2996985678 hasConcept C33923547 @default.
- W2996985678 hasConcept C502942594 @default.
- W2996985678 hasConcept C509974204 @default.
- W2996985678 hasConcept C521977710 @default.
- W2996985678 hasConcept C55493867 @default.
- W2996985678 hasConcept C71924100 @default.
- W2996985678 hasConcept C86803240 @default.
- W2996985678 hasConceptScore W2996985678C112613896 @default.
- W2996985678 hasConceptScore W2996985678C12554922 @default.
- W2996985678 hasConceptScore W2996985678C126322002 @default.
- W2996985678 hasConceptScore W2996985678C134306372 @default.
- W2996985678 hasConceptScore W2996985678C150903083 @default.
- W2996985678 hasConceptScore W2996985678C155672457 @default.
- W2996985678 hasConceptScore W2996985678C16387964 @default.
- W2996985678 hasConceptScore W2996985678C171250308 @default.
- W2996985678 hasConceptScore W2996985678C178790620 @default.
- W2996985678 hasConceptScore W2996985678C185592680 @default.