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• W2996995536 endingPage "103965" @default.
• W2996995536 startingPage "103965" @default.
• W2996995536 abstract "Coxsackie B viruses (CV–B) are associated with several central nervous system (CNS) disorders. These viruses are predominantly transmitted by fecal-oral route but vertical transmission can also occur. This work attempted to study the immune response ensuing vertical transmission of CV-B to the brain, and its eventual implementation in the brain pathogenesis. To this end, pregnant Swiss albino mice were inoculated with CV-B4 E2 or with sterile medium for control animals. At different ages after birth, brains were collected and analyzed for virus infection, histopathological changes and immune response. Infectious particles were detected in offspring's brain which demonstrates vertical transmission of the virus. This infection is persistent since the long lasting detection of viral RNA in offspring's brain. Some pathological signs including meningitis, edema and accumulation of inflammatory cells within and surrounding the inflammatory areas were observed. Immunoflorescence staining unveiled the presence of T lymphocytes and microgliosis in the sites of lesion for a long period after birth. Multiplex cytokines measurement upon supernatants of in vitro mixed brain cells and extracted mononuclear cells from offspring's brain has demonstrated an elevated secretion of the pro-inflammatory cytokines TNFα, IL-6 and IFNα and the chemokines RANTES and MCP-1. Hence, vertical transmission of CV-B4 and its persistence within offspring's brain can lead to pathological features linked to increased and sustained immune response." @default.
• W2996995536 created "2020-01-10" @default.
• W2996995536 creator A5009838281 @default.
• W2996995536 creator A5011983078 @default.
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• W2996995536 creator A5033408025 @default.
• W2996995536 creator A5075582569 @default.
• W2996995536 creator A5079298396 @default.
• W2996995536 date "2020-03-01" @default.
• W2996995536 modified "2023-10-17" @default.
• W2996995536 title "Immunopathology in the brain of mice following vertical transmission of Coxsackievirus B4" @default.
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