Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997029751> ?p ?o ?g. }
- W2997029751 endingPage "130" @default.
- W2997029751 startingPage "130" @default.
- W2997029751 abstract "Resin (co)monomers issued from restorative dental materials are able to distribute in the dental pulp or the gingiva, to get to the saliva and to the flowing blood. Many authors have recently shown that methacrylate-based resins, in particular 2-hydroxyethylmethacrylate (HEMA), are responsible of inflammatory and autophagic processes in human dental pulp stem cells (hDPSCs) while ascorbic acid (AS), an antioxidant molecule, can assume a protective role in cell homeostasis. The purpose of the current work was to study if 50 µg/mL AS can affect the inflammatory status induced by 2 mM HEMA in hDPSCs, a tissue–specific cell population. Cell proliferation, cytokine release, morphological arrangement and reactive oxygen species (ROS) formation were determined respectively by MTT, ELISA, morphological analysis and dichlorofluorescein assay. The hDPSCs exposed to HEMA let to an increment of ROS formation and in the expression of high levels of inflammatory mediators such as nuclear factor-κB (NFkB), inflammatory cytokines such as interleukin IL6, IL8, interferon (IFN)ɣ and monocyte chemoattractant protein (MCP)1. Moreover, HEMA induced the up-regulation of pospho-extracellular signal–regulated kinases (pERK)/ERK signaling pathway associated to the nuclear translocation. AS treatment significantly down-regulated the levels of pro-inflammatory mediators. Then, the natural product AS reduced the detrimental result promoted by methacrylates in clinical dentistry, in fact restore cell proliferation, reduce the pro-inflammatory cytokine, downregulate ROS production and of NFkB/pERK/ERK signaling path. In synthesis, AS, could improve the quality of dental care and play a strategic role as innovative endodontic compound easy to use and with reasonable cost." @default.
- W2997029751 created "2020-01-10" @default.
- W2997029751 creator A5003191623 @default.
- W2997029751 creator A5011608324 @default.
- W2997029751 creator A5026786600 @default.
- W2997029751 creator A5041972310 @default.
- W2997029751 creator A5068820892 @default.
- W2997029751 creator A5069387858 @default.
- W2997029751 creator A5078032532 @default.
- W2997029751 creator A5078313046 @default.
- W2997029751 date "2019-12-27" @default.
- W2997029751 modified "2023-10-05" @default.
- W2997029751 title "A Novel Role of Ascorbic Acid in Anti-Inflammatory Pathway and ROS Generation in HEMA Treated Dental Pulp Stem Cells" @default.
- W2997029751 cites W1834782604 @default.
- W2997029751 cites W1858019207 @default.
- W2997029751 cites W1966609569 @default.
- W2997029751 cites W1968784709 @default.
- W2997029751 cites W1987833986 @default.
- W2997029751 cites W1989477670 @default.
- W2997029751 cites W1990731936 @default.
- W2997029751 cites W2000382687 @default.
- W2997029751 cites W2001954050 @default.
- W2997029751 cites W2004176366 @default.
- W2997029751 cites W2006498503 @default.
- W2997029751 cites W2008484769 @default.
- W2997029751 cites W2025458261 @default.
- W2997029751 cites W2027599695 @default.
- W2997029751 cites W2028333787 @default.
- W2997029751 cites W2036566995 @default.
- W2997029751 cites W2036903519 @default.
- W2997029751 cites W2038254164 @default.
- W2997029751 cites W2042101534 @default.
- W2997029751 cites W2042804612 @default.
- W2997029751 cites W2043823247 @default.
- W2997029751 cites W2053022803 @default.
- W2997029751 cites W2055524515 @default.
- W2997029751 cites W2060637658 @default.
- W2997029751 cites W2068300781 @default.
- W2997029751 cites W2071579893 @default.
- W2997029751 cites W2072101440 @default.
- W2997029751 cites W2087515131 @default.
- W2997029751 cites W2088661873 @default.
- W2997029751 cites W2091864583 @default.
- W2997029751 cites W2102785500 @default.
- W2997029751 cites W2111010707 @default.
- W2997029751 cites W2113306636 @default.
- W2997029751 cites W2120862638 @default.
- W2997029751 cites W2123791769 @default.
- W2997029751 cites W2136201861 @default.
- W2997029751 cites W2139770322 @default.
- W2997029751 cites W2143272819 @default.
- W2997029751 cites W2148861161 @default.
- W2997029751 cites W2160569622 @default.
- W2997029751 cites W2161975983 @default.
- W2997029751 cites W2167279371 @default.
- W2997029751 cites W2192309016 @default.
- W2997029751 cites W2229105716 @default.
- W2997029751 cites W2237088227 @default.
- W2997029751 cites W2257410369 @default.
- W2997029751 cites W2309117218 @default.
- W2997029751 cites W2319792601 @default.
- W2997029751 cites W2339151097 @default.
- W2997029751 cites W2410100688 @default.
- W2997029751 cites W2411347346 @default.
- W2997029751 cites W2415594644 @default.
- W2997029751 cites W2554901135 @default.
- W2997029751 cites W2596948186 @default.
- W2997029751 cites W2612217858 @default.
- W2997029751 cites W2623981860 @default.
- W2997029751 cites W2746918144 @default.
- W2997029751 cites W2752810527 @default.
- W2997029751 cites W2761756049 @default.
- W2997029751 cites W2768727750 @default.
- W2997029751 cites W2769219574 @default.
- W2997029751 cites W2787854391 @default.
- W2997029751 cites W2788348835 @default.
- W2997029751 cites W2794643830 @default.
- W2997029751 cites W2809753590 @default.
- W2997029751 cites W2897663925 @default.
- W2997029751 cites W2903494328 @default.
- W2997029751 cites W2911953056 @default.
- W2997029751 cites W2916194874 @default.
- W2997029751 cites W2927600111 @default.
- W2997029751 cites W2927928920 @default.
- W2997029751 cites W2943824340 @default.
- W2997029751 cites W2947383444 @default.
- W2997029751 cites W2949233742 @default.
- W2997029751 cites W2959240401 @default.
- W2997029751 cites W2971575115 @default.
- W2997029751 cites W2982698032 @default.
- W2997029751 cites W4239177466 @default.
- W2997029751 doi "https://doi.org/10.3390/ma13010130" @default.
- W2997029751 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6981406" @default.
- W2997029751 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31892218" @default.
- W2997029751 hasPublicationYear "2019" @default.
- W2997029751 type Work @default.
- W2997029751 sameAs 2997029751 @default.
- W2997029751 citedByCount "31" @default.