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• W2997031907 endingPage "105681" @default.
• W2997031907 startingPage "105681" @default.
• W2997031907 abstract "Arginine methylation plays essential roles in post-transcriptional modification and signal transduction. Dysregulation of protein arginine methyltransferases (PRMTs) has been reported in human cancers, yet the expression and biological function of PRMT6 in endometrial cancer (EMC) remains unclear. Here, we show that PRMT6 is upregulated in EMC and exhibits oncogenic activities via activation of AKT/mTOR pathway. The expression of PRMT6 in EMC is much higher than that in the adjacent nontumorous tissues. Elevated PRMT6 expression is significantly associated with higher histological tumor grade and unfavorable prognosis in two independent cohorts consisting of a total of 564 patients with EMC. In vitro data demonstrate that PRMT6 expression was identified as a downstream target of miR-372-3p. Ectopic expression of miR-372-3p downregulates PRMT6. Overexpression of PRMT6 promotes EMC cell proliferation and migration, whereas knockdown of PRMT6 leads to opposite phenotypes. Mechanistically, PRMT6 induces the phosphorylation of AKT and mTOR in EMC cells. Inhibition of AKT/mTOR signaling by MK2206 or rapamycin attenuates the PRMT6-mediated EMC progression. In clinical samples, high expression of PRMT6 was correlated to low expression of miR-372-3p and high expression of phosphorylated AKT. Collectively, our findings suggest PRMT6 may function as an oncogene to promote tumor progression, and be of prognostic value to predict disease-free survival of patients with EMC. The newly identified miR-372-3p/PRMT6/AKT/mTOR axis represents a new promising target for EMC management." @default.
• W2997031907 created "2020-01-10" @default.
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• W2997031907 date "2020-03-01" @default.
• W2997031907 modified "2023-10-17" @default.
• W2997031907 title "PRMT6 promotes endometrial cancer via AKT/mTOR signaling and indicates poor prognosis" @default.
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• W2997031907 doi "https://doi.org/10.1016/j.biocel.2019.105681" @default.
• W2997031907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31884111" @default.
• W2997031907 hasPublicationYear "2020" @default.
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