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- W2997044237 endingPage "71" @default.
- W2997044237 startingPage "71" @default.
- W2997044237 abstract "Colorectal cancer (CRC) is one of the leading causes of cancer mortality. Angiogenesis is a rate-determining step in CRC development and metastasis. The balance of angiogenic and antiangiogenic factors is crucial in this process. Angiogenesis-related genes can be regulated post-transcriptionally by microRNAs (miRNAs) and some miRNAs have been shown to shuttle between tumor cells and the tumor microenvironment (TME). MiRNAs have context-dependent actions and can promote or suppress angiogenesis dependent on the type of cancer. On the one hand, miRNAs downregulate anti-angiogenic targets and lead to angiogenesis induction. Tumor suppressor miRNAs, on the other hand, enhance anti-angiogenic response by targeting pro-angiogenic factors. Understanding the interaction between these miRNAs and their target mRNAs will help to unravel molecular mechanisms involved in CRC progression. The aim of this article is to review the current literature on angioregulatory miRNAs in CRC." @default.
- W2997044237 created "2020-01-10" @default.
- W2997044237 creator A5005201111 @default.
- W2997044237 creator A5007146534 @default.
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- W2997044237 creator A5033125669 @default.
- W2997044237 creator A5043358605 @default.
- W2997044237 creator A5058024978 @default.
- W2997044237 date "2019-12-26" @default.
- W2997044237 modified "2023-10-17" @default.
- W2997044237 title "Angioregulatory microRNAs in Colorectal Cancer" @default.
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