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- W2997068572 abstract "Abstract The oral delivery of bile-based vesicles (BBVs) has been limited by their poor physical stability, low drug load and slow absorption rate. The novel consolidated bile-based vesicles/self-nanoemulsifying system (CBBVs/SNES) combines the advantages of vesicular and self-nanoemulsifying systems (SNES). This work aimed to prepare physically stable CBBVs/SNES loaded with the full dose of amlodipine besylate (AB) as model drug. AB-loaded BBVs dispersion was optimized using Box-Behnken design and evaluated for particle size distribution, encapsulation efficiency and solubilization efficiency. AB-loaded CBBVs/SNES was prepared by mixing the vesicles of the optimized BBV with Labrafil-based SNES that gave the highest drug solubility. AB-loaded CBBVs/SNES was evaluated for particle size, Polydispersity index (PDI) and in vitro release. When diluted in GIT fluids, consolidated system spontaneously emulsifies forming nanosized oil droplets and in-situ formed mixed micelles. The formation of nanosized mixed micelles (" @default.
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- W2997068572 date "2020-04-01" @default.
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- W2997068572 title "Consolidated bile-based vesicles/self-nanoemulsifying system (CBBVs/SNES) as a solution for limitations of oral delivery of vesicular dispersions: In-vitro optimization and elucidation of ex-vivo intestinal transport mechanisms" @default.
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- W2997068572 doi "https://doi.org/10.1016/j.jddst.2019.101489" @default.
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