Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997083516> ?p ?o ?g. }
- W2997083516 endingPage "4" @default.
- W2997083516 startingPage "4" @default.
- W2997083516 abstract "Endothelial cells are the main determinants of vascular function, since their dysfunction in response to a series of cardiovascular risk factors is responsible for disease progression and further consequences. Endothelial dysfunction, if not resolved, further aggravates the oxidative status and vessel wall inflammation, thus igniting a vicious cycle. We have furthermore to consider the physiological manifestation of vascular dysfunction and chronic low-grade inflammation during ageing, also known as inflammageing. Based on these considerations, knowledge of the molecular mechanism(s) responsible for endothelial loss-of-function can be pivotal to identify novel targets of intervention with the aim of maintaining endothelial wellness and vessel trophism and function. In this review we have examined the role of the detoxifying enzyme aldehyde dehydrogenase 2 (ALDH2) in the maintenance of endothelial function. Its impairment indeed is associated with oxidative stress and ageing, and in the development of atherosclerosis and neurodegenerative diseases. Strategies to improve its expression and activity may be beneficial in these largely diffused disorders." @default.
- W2997083516 created "2020-01-10" @default.
- W2997083516 creator A5037361041 @default.
- W2997083516 creator A5076622030 @default.
- W2997083516 creator A5085634928 @default.
- W2997083516 creator A5086541070 @default.
- W2997083516 date "2020-01-03" @default.
- W2997083516 modified "2023-10-15" @default.
- W2997083516 title "Endothelial Aldehyde Dehydrogenase 2 as a Target to Maintain Vascular Wellness and Function in Ageing" @default.
- W2997083516 cites W148771838 @default.
- W2997083516 cites W1805975457 @default.
- W2997083516 cites W1871227584 @default.
- W2997083516 cites W1918102602 @default.
- W2997083516 cites W1973320429 @default.
- W2997083516 cites W1982998217 @default.
- W2997083516 cites W1983704379 @default.
- W2997083516 cites W1986623914 @default.
- W2997083516 cites W1995197383 @default.
- W2997083516 cites W2010632526 @default.
- W2997083516 cites W2031880534 @default.
- W2997083516 cites W2037703016 @default.
- W2997083516 cites W2039180364 @default.
- W2997083516 cites W2052547401 @default.
- W2997083516 cites W2058729222 @default.
- W2997083516 cites W2066223468 @default.
- W2997083516 cites W2072714435 @default.
- W2997083516 cites W2075303826 @default.
- W2997083516 cites W2076153333 @default.
- W2997083516 cites W2077535449 @default.
- W2997083516 cites W2081600877 @default.
- W2997083516 cites W2082120711 @default.
- W2997083516 cites W2087619081 @default.
- W2997083516 cites W2087812901 @default.
- W2997083516 cites W2091034186 @default.
- W2997083516 cites W2094341204 @default.
- W2997083516 cites W2097223877 @default.
- W2997083516 cites W2099221133 @default.
- W2997083516 cites W2099428721 @default.
- W2997083516 cites W2105074740 @default.
- W2997083516 cites W2110549318 @default.
- W2997083516 cites W2127867346 @default.
- W2997083516 cites W2136280572 @default.
- W2997083516 cites W2141262291 @default.
- W2997083516 cites W2142194547 @default.
- W2997083516 cites W2155277210 @default.
- W2997083516 cites W2163112976 @default.
- W2997083516 cites W2165470282 @default.
- W2997083516 cites W2231679410 @default.
- W2997083516 cites W2301132053 @default.
- W2997083516 cites W2357868452 @default.
- W2997083516 cites W2421987137 @default.
- W2997083516 cites W2494134352 @default.
- W2997083516 cites W2525185519 @default.
- W2997083516 cites W2530714323 @default.
- W2997083516 cites W2565429613 @default.
- W2997083516 cites W2739174192 @default.
- W2997083516 cites W2748525150 @default.
- W2997083516 cites W2765772163 @default.
- W2997083516 cites W2794933721 @default.
- W2997083516 cites W2800471357 @default.
- W2997083516 cites W2801015568 @default.
- W2997083516 cites W2801293053 @default.
- W2997083516 cites W2803815839 @default.
- W2997083516 cites W2884737578 @default.
- W2997083516 cites W2889787078 @default.
- W2997083516 cites W2894493189 @default.
- W2997083516 cites W2900743432 @default.
- W2997083516 cites W2902395760 @default.
- W2997083516 cites W2904710179 @default.
- W2997083516 cites W2904986197 @default.
- W2997083516 cites W2910769552 @default.
- W2997083516 cites W2911545782 @default.
- W2997083516 cites W2911785505 @default.
- W2997083516 cites W2964034787 @default.
- W2997083516 cites W2964380227 @default.
- W2997083516 cites W2964525320 @default.
- W2997083516 cites W2984037760 @default.
- W2997083516 cites W811443233 @default.
- W2997083516 doi "https://doi.org/10.3390/biomedicines8010004" @default.
- W2997083516 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7168060" @default.
- W2997083516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31947800" @default.
- W2997083516 hasPublicationYear "2020" @default.
- W2997083516 type Work @default.
- W2997083516 sameAs 2997083516 @default.
- W2997083516 citedByCount "15" @default.
- W2997083516 countsByYear W29970835162020 @default.
- W2997083516 countsByYear W29970835162021 @default.
- W2997083516 countsByYear W29970835162022 @default.
- W2997083516 countsByYear W29970835162023 @default.
- W2997083516 crossrefType "journal-article" @default.
- W2997083516 hasAuthorship W2997083516A5037361041 @default.
- W2997083516 hasAuthorship W2997083516A5076622030 @default.
- W2997083516 hasAuthorship W2997083516A5085634928 @default.
- W2997083516 hasAuthorship W2997083516A5086541070 @default.
- W2997083516 hasBestOaLocation W29970835161 @default.
- W2997083516 hasConcept C126322002 @default.
- W2997083516 hasConcept C181199279 @default.
- W2997083516 hasConcept C203014093 @default.