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- W2997128616 endingPage "832" @default.
- W2997128616 startingPage "818" @default.
- W2997128616 abstract "Crystals and nano‐ and microparticles form inside the human body from intrinsic proteins, minerals, or metabolites or enter the body as particulate matter from occupational and environmental sources. Associated tissue injuries and diseases mostly develop from cellular responses to such crystal deposits and include inflammation, cell necrosis, granuloma formation, tissue fibrosis, and stone‐related obstruction of excretory organs. But how do crystals and nano‐ and microparticles trigger these biological processes? Which pathomechanisms are identical across different particle types, sizes, and shapes? In addition, which mechanisms are specific to the atomic or molecular structure of crystals or to specific sizes or shapes? Do specific cellular or molecular mechanisms qualify as target for therapeutic interventions? Here, we provide a guide to approach this diverse and multidisciplinary research domain. We give an overview about the clinical spectrum of crystallopathies, about shared and specific pathomechanisms as a conceptual overview before digging deeper into the specialty field of interest." @default.
- W2997128616 created "2020-01-10" @default.
- W2997128616 creator A5020103420 @default.
- W2997128616 creator A5032822699 @default.
- W2997128616 creator A5066392265 @default.
- W2997128616 creator A5091004058 @default.
- W2997128616 date "2020-01-01" @default.
- W2997128616 modified "2023-10-18" @default.
- W2997128616 title "A guide to crystal‐related and nano‐ or microparticle‐related tissue responses" @default.
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