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• W2997130110 endingPage "102706" @default.
• W2997130110 startingPage "102706" @default.
• W2997130110 abstract "Maternal alloimmunization to paternally inherited antigens on fetal/neonatal platelets can cause fetal/neonatal alloimmune thrombocytopenia (FNAIT) after antibody-mediated removal of platelets from the fetal circulation. The complications vary from mild bleeding symptoms to severe intracranial hemorrhage and subsequent neurological impairment or death. Studies on in vivo mechanisms are challenging to measure directly in pregnant women, rendering murine models as valuable and attractive alternatives, despite some critical differences between mice and men affecting the translational value. Here we present and discuss, the different murine models that substantially have increased our knowledge and understanding of FNAIT pathogenesis - as well as pre-clinical evaluation of therapeutic and preventive strategies." @default.
• W2997130110 created "2020-01-10" @default.
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• W2997130110 date "2020-02-01" @default.
• W2997130110 modified "2023-10-14" @default.
• W2997130110 title "Murine models for studying treatment, prevention and pathogenesis of FNAIT" @default.
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• W2997130110 doi "https://doi.org/10.1016/j.transci.2019.102706" @default.
• W2997130110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31948916" @default.
• W2997130110 hasPublicationYear "2020" @default.
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