FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997131977> ?p ?o ?g. }

• W2997131977 endingPage "1488" @default.
• W2997131977 startingPage "1476" @default.
• W2997131977 abstract "Macroautophagy has been implicated in modulating the therapeutic function of mesenchymal stromal cells (MSCs). However, the biological function of chaperone-mediated autophagy (CMA) in MSCs remains elusive. Here, we found that CMA was inhibited in MSCs in response to the proinflammatory cytokines interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α). In addition, suppression of CMA by knocking down the CMA-related lysosomal receptor lysosomal-associated membrane protein 2 (LAMP-2A) in MSCs significantly enhanced the immunosuppressive effect of MSCs on T cell proliferation, and as expected, LAMP-2A overexpression in MSCs exerted the opposite effect on T cell proliferation. This effect of CMA on the immunosuppressive function of MSCs was attributed to its negative regulation of the expression of chemokine C-X-C motif ligand 10 (CXCL10), which recruits inflammatory cells, especially T cells, to MSCs, and inducible nitric oxide synthase (iNOS), which leads to the subsequent inhibition of T cell proliferation via nitric oxide (NO). Mechanistically, CMA inhibition dramatically promoted IFN-γ plus TNF-α-induced activation of NF-κB and STAT1, leading to the enhanced expression of CXCL10 and iNOS in MSCs. Furthermore, we found that IFN-γ plus TNF-α-induced AKT activation contributed to CMA inhibition in MSCs. More interestingly, CMA-deficient MSCs exhibited improved therapeutic efficacy in inflammatory liver injury. Taken together, our findings established CMA inhibition as a critical contributor to the immunosuppressive function of MSCs induced by inflammatory cytokines and highlighted a previously unknown function of CMA." @default.
• W2997131977 created "2020-01-10" @default.
• W2997131977 creator A5006446712 @default.
• W2997131977 creator A5008921604 @default.
• W2997131977 creator A5011322561 @default.
• W2997131977 creator A5013884567 @default.
• W2997131977 creator A5017522835 @default.
• W2997131977 creator A5020383361 @default.
• W2997131977 creator A5034833074 @default.
• W2997131977 creator A5056626227 @default.
• W2997131977 creator A5063126731 @default.
• W2997131977 creator A5066123521 @default.
• W2997131977 creator A5068070422 @default.
• W2997131977 creator A5073501391 @default.
• W2997131977 creator A5076990905 @default.
• W2997131977 creator A5089096739 @default.
• W2997131977 date "2020-01-03" @default.
• W2997131977 modified "2023-10-10" @default.
• W2997131977 title "Inflammation-induced inhibition of chaperone-mediated autophagy maintains the immunosuppressive function of murine mesenchymal stromal cells" @default.
• W2997131977 cites W1493534235 @default.
• W2997131977 cites W1598733325 @default.
• W2997131977 cites W1916749819 @default.
• W2997131977 cites W1979043688 @default.
• W2997131977 cites W1981736380 @default.
• W2997131977 cites W1985408391 @default.
• W2997131977 cites W2004396698 @default.
• W2997131977 cites W2013389256 @default.
• W2997131977 cites W2017402654 @default.
• W2997131977 cites W2020335918 @default.
• W2997131977 cites W2021919397 @default.
• W2997131977 cites W2024326908 @default.
• W2997131977 cites W2026531364 @default.
• W2997131977 cites W2046669934 @default.
• W2997131977 cites W2053362289 @default.
• W2997131977 cites W2053984526 @default.
• W2997131977 cites W2055004642 @default.
• W2997131977 cites W2060020051 @default.
• W2997131977 cites W2061175761 @default.
• W2997131977 cites W2072321567 @default.
• W2997131977 cites W2079123204 @default.
• W2997131977 cites W2092713669 @default.
• W2997131977 cites W2097227226 @default.
• W2997131977 cites W2101962395 @default.
• W2997131977 cites W2110414630 @default.
• W2997131977 cites W2116258912 @default.
• W2997131977 cites W2148976095 @default.
• W2997131977 cites W2166672922 @default.
• W2997131977 cites W2168445378 @default.
• W2997131977 cites W2214208728 @default.
• W2997131977 cites W2274034874 @default.
• W2997131977 cites W2310326609 @default.
• W2997131977 cites W2344331208 @default.
• W2997131977 cites W2543650474 @default.
• W2997131977 cites W2581599154 @default.
• W2997131977 cites W2590533908 @default.
• W2997131977 cites W2763905358 @default.
• W2997131977 cites W2784233957 @default.
• W2997131977 cites W2801492357 @default.
• W2997131977 cites W2808158796 @default.
• W2997131977 cites W2913303186 @default.
• W2997131977 doi "https://doi.org/10.1038/s41423-019-0345-7" @default.
• W2997131977 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8167126" @default.
• W2997131977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31900460" @default.
• W2997131977 hasPublicationYear "2020" @default.
• W2997131977 type Work @default.
• W2997131977 sameAs 2997131977 @default.
• W2997131977 citedByCount "16" @default.
• W2997131977 countsByYear W29971319772020 @default.
• W2997131977 countsByYear W29971319772021 @default.
• W2997131977 countsByYear W29971319772022 @default.
• W2997131977 countsByYear W29971319772023 @default.
• W2997131977 crossrefType "journal-article" @default.
• W2997131977 hasAuthorship W2997131977A5006446712 @default.
• W2997131977 hasAuthorship W2997131977A5008921604 @default.
• W2997131977 hasAuthorship W2997131977A5011322561 @default.
• W2997131977 hasAuthorship W2997131977A5013884567 @default.
• W2997131977 hasAuthorship W2997131977A5017522835 @default.
• W2997131977 hasAuthorship W2997131977A5020383361 @default.
• W2997131977 hasAuthorship W2997131977A5034833074 @default.
• W2997131977 hasAuthorship W2997131977A5056626227 @default.
• W2997131977 hasAuthorship W2997131977A5063126731 @default.
• W2997131977 hasAuthorship W2997131977A5066123521 @default.
• W2997131977 hasAuthorship W2997131977A5068070422 @default.
• W2997131977 hasAuthorship W2997131977A5073501391 @default.
• W2997131977 hasAuthorship W2997131977A5076990905 @default.
• W2997131977 hasAuthorship W2997131977A5089096739 @default.
• W2997131977 hasBestOaLocation W29971319771 @default.
• W2997131977 hasConcept C13373296 @default.
• W2997131977 hasConcept C164027704 @default.
• W2997131977 hasConcept C17991360 @default.
• W2997131977 hasConcept C185592680 @default.
• W2997131977 hasConcept C190283241 @default.
• W2997131977 hasConcept C198826908 @default.
• W2997131977 hasConcept C203014093 @default.
• W2997131977 hasConcept C203522944 @default.
• W2997131977 hasConcept C2776914184 @default.
• W2997131977 hasConcept C502942594 @default.
• W2997131977 hasConcept C55493867 @default.

• next