FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997132350> ?p ?o ?g. }

• W2997132350 endingPage "491" @default.
• W2997132350 startingPage "479" @default.
• W2997132350 abstract "N-methyl-D-aspartate receptors (NMDARs) are glutamate-activated, heterotetrameric ligand-gated ion channels critically important in virtually all aspects of glutamatergic signaling. Ethanol (EtOH) inhibition of NMDARs is thought to mediate specific actions of EtOH during acute and chronic exposure. Studies from our laboratory, and others, identified EtOH-sensitive sites within specific transmembrane (TM) domains involved in channel gating as well as those in subdomains of extracellular and intracellular regions of GluN1 and GluN2 subunits that affect channel function. In this study, we characterize for the first time the physiological and behavioral effects of EtOH on knock-in mice expressing a GluN2A subunit that shows reduced sensitivity to EtOH.A battery of tests evaluating locomotion, anxiety, sedation, motor coordination, and voluntary alcohol intake were performed in wild-type mice and those expressing the GluN2A A825W knock-in mutation. Whole-cell patch-clamp electrophysiological recordings were used to confirm reduced EtOH sensitivity of NMDAR-mediated currents in 2 separate brain regions (mPFC and the cerebellum) where the GluN2A subunit is known to contribute to NMDAR-mediated responses.Male and female mice homozygous for the GluN2A(A825W) knock-in mutation showed reduced EtOH inhibition of NMDAR-mediated synaptic currents in mPFC and cerebellar neurons as compared to their wild-type counterparts. GluN2A(A825W) male but not female mice were less sensitive to the sedative and motor-incoordinating effects of EtOH and showed a rightward shift in locomotor-stimulating effects of EtOH. There was no effect of the mutation on EtOH-induced anxiolysis or voluntary EtOH consumption in either male or female mice.These findings show that expression of EtOH-resistant GluN2A NMDARs results in selective and sex-specific changes in the behavioral sensitivity to EtOH." @default.
• W2997132350 created "2020-01-10" @default.
• W2997132350 creator A5056381264 @default.
• W2997132350 creator A5059887426 @default.
• W2997132350 creator A5072610252 @default.
• W2997132350 creator A5081525770 @default.
• W2997132350 date "2020-01-14" @default.
• W2997132350 modified "2023-10-15" @default.
• W2997132350 title "Knock‐in Mice Expressing an Ethanol‐Resistant GluN2A NMDA Receptor Subunit Show Altered Responses to Ethanol" @default.
• W2997132350 cites W1495287328 @default.
• W2997132350 cites W1504476709 @default.
• W2997132350 cites W1579354630 @default.
• W2997132350 cites W1966673980 @default.
• W2997132350 cites W1966697925 @default.
• W2997132350 cites W1967032407 @default.
• W2997132350 cites W1972428815 @default.
• W2997132350 cites W1977546136 @default.
• W2997132350 cites W1981032249 @default.
• W2997132350 cites W1991120029 @default.
• W2997132350 cites W1997663774 @default.
• W2997132350 cites W2000853777 @default.
• W2997132350 cites W2003110203 @default.
• W2997132350 cites W2011429118 @default.
• W2997132350 cites W2020200626 @default.
• W2997132350 cites W2021284505 @default.
• W2997132350 cites W2037654926 @default.
• W2997132350 cites W2037852973 @default.
• W2997132350 cites W2042646500 @default.
• W2997132350 cites W2044818530 @default.
• W2997132350 cites W2045165595 @default.
• W2997132350 cites W2056778894 @default.
• W2997132350 cites W2068492591 @default.
• W2997132350 cites W2069444651 @default.
• W2997132350 cites W2075276600 @default.
• W2997132350 cites W2085049245 @default.
• W2997132350 cites W2094080960 @default.
• W2997132350 cites W2105726924 @default.
• W2997132350 cites W2107001816 @default.
• W2997132350 cites W2112606475 @default.
• W2997132350 cites W2114533624 @default.
• W2997132350 cites W2122223483 @default.
• W2997132350 cites W2129301099 @default.
• W2997132350 cites W2135165474 @default.
• W2997132350 cites W2154196572 @default.
• W2997132350 cites W2163891182 @default.
• W2997132350 cites W2165985411 @default.
• W2997132350 cites W2166486263 @default.
• W2997132350 cites W2171581013 @default.
• W2997132350 cites W2181518245 @default.
• W2997132350 cites W2303293665 @default.
• W2997132350 cites W2462360006 @default.
• W2997132350 cites W2502675103 @default.
• W2997132350 cites W2529595367 @default.
• W2997132350 cites W2547648483 @default.
• W2997132350 cites W2570737967 @default.
• W2997132350 cites W2590617516 @default.
• W2997132350 cites W2602811693 @default.
• W2997132350 cites W2782840478 @default.
• W2997132350 cites W2893001433 @default.
• W2997132350 cites W4210950533 @default.
• W2997132350 cites W623506756 @default.
• W2997132350 cites W67853578 @default.
• W2997132350 cites W2811499973 @default.
• W2997132350 doi "https://doi.org/10.1111/acer.14273" @default.
• W2997132350 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7018579" @default.
• W2997132350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31872888" @default.
• W2997132350 hasPublicationYear "2020" @default.
• W2997132350 type Work @default.
• W2997132350 sameAs 2997132350 @default.
• W2997132350 citedByCount "9" @default.
• W2997132350 countsByYear W29971323502020 @default.
• W2997132350 countsByYear W29971323502021 @default.
• W2997132350 countsByYear W29971323502022 @default.
• W2997132350 countsByYear W29971323502023 @default.
• W2997132350 crossrefType "journal-article" @default.
• W2997132350 hasAuthorship W2997132350A5056381264 @default.
• W2997132350 hasAuthorship W2997132350A5059887426 @default.
• W2997132350 hasAuthorship W2997132350A5072610252 @default.
• W2997132350 hasAuthorship W2997132350A5081525770 @default.
• W2997132350 hasBestOaLocation W29971323502 @default.
• W2997132350 hasConcept C104292427 @default.
• W2997132350 hasConcept C104317684 @default.
• W2997132350 hasConcept C113062710 @default.
• W2997132350 hasConcept C147944092 @default.
• W2997132350 hasConcept C160268369 @default.
• W2997132350 hasConcept C168258287 @default.
• W2997132350 hasConcept C169760540 @default.
• W2997132350 hasConcept C170493617 @default.
• W2997132350 hasConcept C185263204 @default.
• W2997132350 hasConcept C185592680 @default.
• W2997132350 hasConcept C2779652256 @default.
• W2997132350 hasConcept C2780648746 @default.
• W2997132350 hasConcept C55493867 @default.
• W2997132350 hasConcept C61174792 @default.
• W2997132350 hasConcept C67018056 @default.
• W2997132350 hasConcept C86803240 @default.
• W2997132350 hasConcept C98274493 @default.
• W2997132350 hasConceptScore W2997132350C104292427 @default.

• next