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- W2997136313 abstract "Purpose: The meta-analysis aims to evaluate the efficacy and safety of terlipressin compared with norepinephrine for septic shock. Materials and Methods: The relevant studies from MEDLINE, Cochrane Library, Embase were searched by two independent investigators. A variety of keywords were used to search the studies. Stata software (version 11.0, Stata Corp LP, College Station, TX, USA) was used for statistical analysis. Results: A total of 6 studies were identified and incorporated into the meta-analysis. The results showed that there was no difference for 28-day mortality (RR=0.99, 95% CI=[0.85,1.15], P=0.849), AE (RR=2.54, 95% CI=[0.58,11.08], P=0.214) and MAP (SMD=-0.10, 95% CI=[-0.35,0.14], P=0.405) , OI, urinary output, Scr, total bilirubin, ALT and AST between TP group and NE group. While, TP could decrease HR at 24h and 48h compared with NE. Conclusions: Current results suggest that terlipressin showed no added survival benefit for septic shock when compared with norepinephrine. While, terlipressin could decrease heart rate in the late phase of septic shock compared with norepinephrine without further liver and kidney injury." @default.
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- W2997136313 date "2019-12-23" @default.
- W2997136313 modified "2023-09-24" @default.
- W2997136313 title "Terlipressin Versus Norepinephrine for Septic Shock: A Systematic Review and Meta-Analysis" @default.
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- W2997136313 doi "https://doi.org/10.3389/fphar.2019.01492" @default.
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