Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997146472> ?p ?o ?g. }
- W2997146472 endingPage "457" @default.
- W2997146472 startingPage "433" @default.
- W2997146472 abstract "Telomeres are protective chromosomal ends that shield the chromosomes from DNA damage, exonucleolytic degradation, recombination, and end-to-end fusion. Telomerase is a ribonucleoprotein that adds TTAGGG tandem repeats to the telomeric ends. It has been observed that 85 to 90% of human tumors express high levels of telomerase, playing a crucial role in the development of cancers. Interestingly, the telomerase activity is generally absent in normal somatic cells. This selective telomerase expression has driven scientists to develop novel anti-cancer therapeutics with high specificity and potency. Several advancements have been made in this area, which is reflected by the enormous success of the anticancer agent Imetelstat. Since the discovery of Imetelstat, several research groups have contributed to enrich the therapeutic arsenal against cancer. Such contributions include the application of new classes of small molecules, peptides, and hTERT-based immunotherapeutic agents (p540, GV1001, GRNVAC1 or combinations of these such as Vx-001). Many of these therapeutic tools are under different stages of clinical trials and have shown promising outcomes. In this review, we highlight the current status of telomerase-based cancer therapeutics and the outcome of these investigations." @default.
- W2997146472 created "2020-01-10" @default.
- W2997146472 creator A5003455919 @default.
- W2997146472 creator A5004950855 @default.
- W2997146472 creator A5010841983 @default.
- W2997146472 creator A5015069863 @default.
- W2997146472 creator A5060371306 @default.
- W2997146472 creator A5061403352 @default.
- W2997146472 creator A5079124576 @default.
- W2997146472 creator A5084867757 @default.
- W2997146472 creator A5088518053 @default.
- W2997146472 creator A5091813286 @default.
- W2997146472 date "2020-04-13" @default.
- W2997146472 modified "2023-09-24" @default.
- W2997146472 title "Telomerase-based Cancer Therapeutics: A Review on their Clinical Trials" @default.
- W2997146472 cites W1485620077 @default.
- W2997146472 cites W1497704183 @default.
- W2997146472 cites W1517051009 @default.
- W2997146472 cites W1521418395 @default.
- W2997146472 cites W1539988689 @default.
- W2997146472 cites W1583495800 @default.
- W2997146472 cites W1653629301 @default.
- W2997146472 cites W1661544713 @default.
- W2997146472 cites W1827784925 @default.
- W2997146472 cites W1829553711 @default.
- W2997146472 cites W1927581912 @default.
- W2997146472 cites W1951952424 @default.
- W2997146472 cites W1966270249 @default.
- W2997146472 cites W1970555729 @default.
- W2997146472 cites W1972393066 @default.
- W2997146472 cites W1980625858 @default.
- W2997146472 cites W1981869069 @default.
- W2997146472 cites W1987294642 @default.
- W2997146472 cites W1993762560 @default.
- W2997146472 cites W1994993231 @default.
- W2997146472 cites W1995541635 @default.
- W2997146472 cites W1996814108 @default.
- W2997146472 cites W1996952541 @default.
- W2997146472 cites W2000046662 @default.
- W2997146472 cites W2000856540 @default.
- W2997146472 cites W2000971601 @default.
- W2997146472 cites W2002601689 @default.
- W2997146472 cites W2006941041 @default.
- W2997146472 cites W2008495999 @default.
- W2997146472 cites W2012116244 @default.
- W2997146472 cites W2013073993 @default.
- W2997146472 cites W2013305758 @default.
- W2997146472 cites W2014414194 @default.
- W2997146472 cites W2015408809 @default.
- W2997146472 cites W2021758398 @default.
- W2997146472 cites W2022086312 @default.
- W2997146472 cites W2026364942 @default.
- W2997146472 cites W2028494658 @default.
- W2997146472 cites W2030209169 @default.
- W2997146472 cites W2030876024 @default.
- W2997146472 cites W2030976397 @default.
- W2997146472 cites W2031745114 @default.
- W2997146472 cites W2031867247 @default.
- W2997146472 cites W2033861401 @default.
- W2997146472 cites W2034540642 @default.
- W2997146472 cites W2035467544 @default.
- W2997146472 cites W2035552696 @default.
- W2997146472 cites W2036594498 @default.
- W2997146472 cites W2037850046 @default.
- W2997146472 cites W2038328054 @default.
- W2997146472 cites W2042122379 @default.
- W2997146472 cites W2042409563 @default.
- W2997146472 cites W2042662562 @default.
- W2997146472 cites W2042727692 @default.
- W2997146472 cites W2042897772 @default.
- W2997146472 cites W2046818057 @default.
- W2997146472 cites W2047984441 @default.
- W2997146472 cites W2048076679 @default.
- W2997146472 cites W2057009728 @default.
- W2997146472 cites W2058286861 @default.
- W2997146472 cites W2060896826 @default.
- W2997146472 cites W2062779626 @default.
- W2997146472 cites W2064507032 @default.
- W2997146472 cites W2065448252 @default.
- W2997146472 cites W2066058593 @default.
- W2997146472 cites W2068628341 @default.
- W2997146472 cites W2073204556 @default.
- W2997146472 cites W2074516592 @default.
- W2997146472 cites W2074616990 @default.
- W2997146472 cites W2077945404 @default.
- W2997146472 cites W2078805336 @default.
- W2997146472 cites W2079378073 @default.
- W2997146472 cites W2079586464 @default.
- W2997146472 cites W2079949890 @default.
- W2997146472 cites W2083500661 @default.
- W2997146472 cites W2084187309 @default.
- W2997146472 cites W2085440649 @default.
- W2997146472 cites W2087011288 @default.
- W2997146472 cites W2094056217 @default.
- W2997146472 cites W2094515964 @default.
- W2997146472 cites W2094652659 @default.
- W2997146472 cites W2096176330 @default.
- W2997146472 cites W2096982451 @default.