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- W2997149669 abstract "ABSTRACT In the canonical process of translation, newly completed proteins escape from the ribosome following cleavage of the ester bond that anchors the polypeptide to the P-site tRNA, after which the ribosome can be recycled to initiate a new round of translation. Not all protein synthesis runs to completion as various factors can impede the progression of ribosomes. Rescuing of stalled ribosomes in mammalian mitochondria, however, does not share the same mechanisms that many bacteria use. The classic method for rescuing bacterial ribosomes is trans-translation. The key components of this system are absent from mammalian mitochondria; however, four members of a translation termination factor family are present, with some evidence of homology to members of a bacterial back-up rescue system. To date, there is no definitive demonstration of any other member of this family functioning in mitoribosome rescue. Here, we provide an overview of the processes and key players of canonical translation termination in both bacteria and mammalian mitochondria, followed by a perspective of the bacterial systems used to rescue stalled ribosomes. We highlight any similarities or differences with the mitochondrial translation release factors, and suggest potential roles for these proteins in ribosome rescue in mammalian mitochondria." @default.
- W2997149669 created "2020-01-10" @default.
- W2997149669 creator A5003252797 @default.
- W2997149669 creator A5009337566 @default.
- W2997149669 creator A5024032202 @default.
- W2997149669 creator A5036075066 @default.
- W2997149669 date "2020-01-01" @default.
- W2997149669 modified "2023-10-04" @default.
- W2997149669 title "Rescuing stalled mammalian mitoribosomes – what can we learn from bacteria?" @default.
- W2997149669 cites W145996033 @default.
- W2997149669 cites W1757331837 @default.
- W2997149669 cites W1926965148 @default.
- W2997149669 cites W1952760662 @default.
- W2997149669 cites W1963870359 @default.
- W2997149669 cites W1964333133 @default.
- W2997149669 cites W1965803462 @default.
- W2997149669 cites W1968202347 @default.
- W2997149669 cites W1974452426 @default.
- W2997149669 cites W1976954198 @default.
- W2997149669 cites W1979129444 @default.
- W2997149669 cites W1979492402 @default.
- W2997149669 cites W1979951442 @default.
- W2997149669 cites W1983989599 @default.
- W2997149669 cites W1986069023 @default.
- W2997149669 cites W1989067983 @default.
- W2997149669 cites W1990868071 @default.
- W2997149669 cites W1991196180 @default.
- W2997149669 cites W1991562832 @default.
- W2997149669 cites W1991719432 @default.
- W2997149669 cites W1993921072 @default.
- W2997149669 cites W1993987952 @default.
- W2997149669 cites W1996259657 @default.
- W2997149669 cites W1996993889 @default.
- W2997149669 cites W1997664790 @default.
- W2997149669 cites W2003439190 @default.
- W2997149669 cites W2006035995 @default.
- W2997149669 cites W2006967140 @default.
- W2997149669 cites W2009882942 @default.
- W2997149669 cites W2012970556 @default.
- W2997149669 cites W2013999085 @default.
- W2997149669 cites W2015178379 @default.
- W2997149669 cites W2017892056 @default.
- W2997149669 cites W2018280419 @default.
- W2997149669 cites W2019741974 @default.
- W2997149669 cites W2025445920 @default.
- W2997149669 cites W2030555025 @default.
- W2997149669 cites W2030577827 @default.
- W2997149669 cites W2031465355 @default.
- W2997149669 cites W2031666563 @default.
- W2997149669 cites W2032279044 @default.
- W2997149669 cites W2037528078 @default.
- W2997149669 cites W2044834852 @default.
- W2997149669 cites W2048382535 @default.
- W2997149669 cites W2051937183 @default.
- W2997149669 cites W2067134743 @default.
- W2997149669 cites W2069524886 @default.
- W2997149669 cites W2073694547 @default.
- W2997149669 cites W2075835114 @default.
- W2997149669 cites W2079583942 @default.
- W2997149669 cites W2079834131 @default.
- W2997149669 cites W2080872178 @default.
- W2997149669 cites W2083119952 @default.
- W2997149669 cites W2083157472 @default.
- W2997149669 cites W2083350250 @default.
- W2997149669 cites W2083796059 @default.
- W2997149669 cites W2084140927 @default.
- W2997149669 cites W2084927470 @default.
- W2997149669 cites W2087092389 @default.
- W2997149669 cites W2087191213 @default.
- W2997149669 cites W2089860149 @default.
- W2997149669 cites W2090583952 @default.
- W2997149669 cites W2093189018 @default.
- W2997149669 cites W2094121487 @default.
- W2997149669 cites W2094508956 @default.
- W2997149669 cites W2101404563 @default.
- W2997149669 cites W2103666721 @default.
- W2997149669 cites W2109291482 @default.
- W2997149669 cites W2110319998 @default.
- W2997149669 cites W2110678358 @default.
- W2997149669 cites W2115809836 @default.
- W2997149669 cites W2117396467 @default.
- W2997149669 cites W2117567932 @default.
- W2997149669 cites W2117915391 @default.
- W2997149669 cites W2122049445 @default.
- W2997149669 cites W2122492401 @default.
- W2997149669 cites W2123577912 @default.
- W2997149669 cites W2128380275 @default.
- W2997149669 cites W2129111957 @default.
- W2997149669 cites W2131293378 @default.
- W2997149669 cites W2131623467 @default.
- W2997149669 cites W2131755085 @default.
- W2997149669 cites W2134915935 @default.
- W2997149669 cites W2135985251 @default.
- W2997149669 cites W2136211980 @default.
- W2997149669 cites W2137444535 @default.
- W2997149669 cites W2138369959 @default.
- W2997149669 cites W2138985110 @default.
- W2997149669 cites W2139530620 @default.
- W2997149669 cites W2141057149 @default.
- W2997149669 cites W2144010612 @default.