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- W2997155217 abstract "Motion sickness (MS) is caused due to sensory mismatch. Sensory conflict theory which proves acetylcholine, histamine elevations as the primary reason for MS provides a path for an effective pharmaco-therapy, by an attempt to inhibit the elevation of acetylcholine, histamine during travel. The present study aimed to screen herbal extracts and their bioactive compounds for anti-MS effect by using in vitro and in vivo models. Ten herbal extracts and their bioactive compounds were tested for its effect on acetylcholine esterase (AChE) activity, histamine and dopamine release in human leukaemia KU812 and rat pheochromocytoma PC12 cells respectively. Rutin hydrate, menthol, eugenol, linalool and hesperidin showed less inhibitory effect on AChE activity and promoting the degradation of acetylcholine and inhibited the release of histamine and dopamine from KU812 and PC12 cells. These bioactive compounds being present in Ocimum basilicum L. var. basilicum seed extract (OBSE) was chosen for further validation studies in vivo. Anti-MS effect was evaluated in BALB/c mice model using conditioned taste aversion. Pre-treatment with OBSE at 300 mg/kg bodyweight concentration prevented MS by reducing acetylcholine, histamine, dopamine, epinephrine levels, cholinergic receptor muscarinic 1 gene expression and increasing serotonin and norepinephrine levels and thus it could serve as a potent herbal antidote for MS." @default.
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- W2997155217 date "2020-05-01" @default.
- W2997155217 modified "2023-10-16" @default.
- W2997155217 title "Evaluation of the effect of herbal extracts and their bioactive compounds against motion sickness by regulating neurotransmitter levels in vitro and in vivo" @default.
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- W2997155217 doi "https://doi.org/10.1016/j.sajb.2019.12.012" @default.
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