Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997191100> ?p ?o ?g. }
- W2997191100 endingPage "401" @default.
- W2997191100 startingPage "390" @default.
- W2997191100 abstract "Fucoidan is a marine polymer extracted from diverse types of brown algae. This polysaccharide showed great potential towards treatment of different types of cancer. In this study, the activity of fucoidan extracted from Undaria Pinnatifida was investigated against pancreatic cancer (one of the most life-threatening cancers). Then, in an attempt to enhance the polymer's activity against cancer cells, conversion the polymer solution to nanoparticles was suggested to enhance its delivery through pancreatic cancer surrounding stroma. Novel fucoidan based nanoparticles were elaborated by polyelectrolyte interaction with the positively charged, active targeting ligand lactoferrin. The formulation was optimized through the interplay between different factors. Effect of fucoidan solution along with its blank nanoparticles was tested on the viability of pancreatic cancer cells and its migration and invasion abilities. Results confirmed the cytotoxic ability of fucoidan against pancreatic cancer. IC50 value decreased by 2.3 folds when the polymer was converted to nanoparticles. The prepared nanosystems showed an enhanced ability to prevent pancreatic cancer cells' migration and invasion. Results suggested the potential of using these nanoparticles as bioactive dual-targeted system either blank or loaded with different anticancer agents for treatment for pancreatic cancer." @default.
- W2997191100 created "2020-01-10" @default.
- W2997191100 creator A5054821696 @default.
- W2997191100 creator A5059444024 @default.
- W2997191100 creator A5087426212 @default.
- W2997191100 date "2020-02-01" @default.
- W2997191100 modified "2023-10-03" @default.
- W2997191100 title "Novel fucoidan based bioactive targeted nanoparticles from Undaria Pinnatifida for treatment of pancreatic cancer" @default.
- W2997191100 cites W1488734028 @default.
- W2997191100 cites W1531994742 @default.
- W2997191100 cites W1842907629 @default.
- W2997191100 cites W193983472 @default.
- W2997191100 cites W1956404913 @default.
- W2997191100 cites W1963793665 @default.
- W2997191100 cites W1967060830 @default.
- W2997191100 cites W1967466408 @default.
- W2997191100 cites W1974056925 @default.
- W2997191100 cites W1980431158 @default.
- W2997191100 cites W1988249582 @default.
- W2997191100 cites W2008152885 @default.
- W2997191100 cites W2014424662 @default.
- W2997191100 cites W2018692723 @default.
- W2997191100 cites W2026385689 @default.
- W2997191100 cites W2029751462 @default.
- W2997191100 cites W2032075598 @default.
- W2997191100 cites W2049432837 @default.
- W2997191100 cites W2070656175 @default.
- W2997191100 cites W2075094948 @default.
- W2997191100 cites W2076254649 @default.
- W2997191100 cites W2083952475 @default.
- W2997191100 cites W2086651095 @default.
- W2997191100 cites W2089352653 @default.
- W2997191100 cites W2092242450 @default.
- W2997191100 cites W2122725069 @default.
- W2997191100 cites W2134321864 @default.
- W2997191100 cites W2135930942 @default.
- W2997191100 cites W2144229261 @default.
- W2997191100 cites W2184277213 @default.
- W2997191100 cites W2192130046 @default.
- W2997191100 cites W2341960776 @default.
- W2997191100 cites W2419197534 @default.
- W2997191100 cites W2460304680 @default.
- W2997191100 cites W2486388873 @default.
- W2997191100 cites W2517435763 @default.
- W2997191100 cites W2525041092 @default.
- W2997191100 cites W2565595174 @default.
- W2997191100 cites W2566470177 @default.
- W2997191100 cites W2587876510 @default.
- W2997191100 cites W2590410234 @default.
- W2997191100 cites W2593627366 @default.
- W2997191100 cites W2599052410 @default.
- W2997191100 cites W2601788623 @default.
- W2997191100 cites W2607576892 @default.
- W2997191100 cites W2617383260 @default.
- W2997191100 cites W2625507852 @default.
- W2997191100 cites W2763539192 @default.
- W2997191100 cites W2765435468 @default.
- W2997191100 cites W2767723038 @default.
- W2997191100 cites W2770303613 @default.
- W2997191100 cites W2781525129 @default.
- W2997191100 cites W2782771962 @default.
- W2997191100 cites W2794674707 @default.
- W2997191100 cites W2795224129 @default.
- W2997191100 cites W2795537524 @default.
- W2997191100 cites W2803593513 @default.
- W2997191100 cites W2808051394 @default.
- W2997191100 cites W2809871933 @default.
- W2997191100 cites W2889733669 @default.
- W2997191100 cites W2889902247 @default.
- W2997191100 cites W2890244060 @default.
- W2997191100 cites W2891829524 @default.
- W2997191100 cites W2900747943 @default.
- W2997191100 cites W2901087285 @default.
- W2997191100 cites W2907910053 @default.
- W2997191100 cites W2908498115 @default.
- W2997191100 cites W2909568111 @default.
- W2997191100 cites W2910636024 @default.
- W2997191100 cites W2924560003 @default.
- W2997191100 cites W2962698399 @default.
- W2997191100 cites W2964580845 @default.
- W2997191100 cites W2970740521 @default.
- W2997191100 cites W2990917916 @default.
- W2997191100 doi "https://doi.org/10.1016/j.ijbiomac.2019.12.177" @default.
- W2997191100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31881303" @default.
- W2997191100 hasPublicationYear "2020" @default.
- W2997191100 type Work @default.
- W2997191100 sameAs 2997191100 @default.
- W2997191100 citedByCount "43" @default.
- W2997191100 countsByYear W29971911002020 @default.
- W2997191100 countsByYear W29971911002021 @default.
- W2997191100 countsByYear W29971911002022 @default.
- W2997191100 countsByYear W29971911002023 @default.
- W2997191100 crossrefType "journal-article" @default.
- W2997191100 hasAuthorship W2997191100A5054821696 @default.
- W2997191100 hasAuthorship W2997191100A5059444024 @default.
- W2997191100 hasAuthorship W2997191100A5087426212 @default.
- W2997191100 hasConcept C100817775 @default.
- W2997191100 hasConcept C121608353 @default.