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• W2997223374 abstract "Abstract Background and aims One‐third of US tobacco users are non‐daily smokers (NDS). Black NDS have strikingly high levels of nicotine and carcinogen exposure. No smoking cessation studies have been conducted with this high‐risk group. This study compared the effectiveness in black NDS of smoking cessation counseling alone or in combination with the participant's choice of nicotine replacement therapy. Design Two‐arm parallel‐group individually randomized clinical trial (allocation ratio of 2 : 1 intervention to control) Setting Academic medical and federally qualified health centers in three US cities. Participants Non‐Hispanic black adult NDS receiving counseling with nicotine replacement therapy (C + NRT, n = 185) or counseling alone (C, n = 93). Interventions Twelve weeks of in‐person and telephone smoking cessation counseling in combination with nicotine replacement therapy (NRT; C + NRT) or counseling alone (C). All participants received five sessions of counseling; those randomized to C + NRT received their choice of nicotine gum, patch and/or lozenge after a 9‐day product trial period. The target quit day was set at 2 weeks post‐baseline for both groups. Measurements Primary outcome was biochemically verified 30‐day abstinence at week 12. Secondary outcomes were change in nicotine and carcinogen exposure [4‐(methynitrosamino)‐1‐(3) pyridyle‐1‐butanol; NNAL] and tobacco consumption patterns. Findings Abstinence was 11.4% in C + NRT and 8.6% in C [odds ratio (OR) = 1.4, 95% confidence interval (CI) = 0.6, 3.2, P = 0.48]. Both groups experienced significant reduction in NNAL (C + NRT: 53% reduction, C: 50% reduction, within‐group P < 0.0001) but non‐significant changes in cotinine ( P = 0.69). C + NRT reported more days abstinent ( P < 0.001) and fewer total cigarettes ( P = 0.002) compared with C. There was no evidence of compensation with other tobacco products. Conclusions Among black non‐daily smokers in the United States, there was no difference in abstinence between nicotine replacement therapy (NRT) and counseling alone. NRT led to greater increase in days abstinent and reduction in cigarettes, with no evidence of compensation from other sources of nicotine." @default.
• W2997223374 created "2020-01-10" @default.
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• W2997223374 date "2020-02-06" @default.
• W2997223374 modified "2023-09-26" @default.
• W2997223374 title "Counseling alone or in combination with nicotine replacement therapy for treatment of black non‐daily smokers: a randomized trial" @default.
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• W2997223374 doi "https://doi.org/10.1111/add.14948" @default.
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