Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997230048> ?p ?o ?g. }
- W2997230048 endingPage "95" @default.
- W2997230048 startingPage "85" @default.
- W2997230048 abstract "Abstract Histone deacetylase 6 (HDAC6) is a unique member of the HDAC family because of its characteristics, namely, its cytoplasmic localization and ubiquitin binding. HDAC6 has been implicated in cancer metastasis and neurodegeneration. In the present study, we performed radiosynthesis and biological evaluation of a fluorine‐18–labeled ligand [ 18 F] 3 , which is an analog of the HDAC6‐selective inhibitor tubastatin A, for positron emission tomography (PET) imaging. [ 18 F] 3 was synthesized by a two‐step reaction composed of 18 F‐fluorination and formation of a hydroxamic acid group. IC 50 values of 3 against HDAC1 and HDAC6 activities were 996 nM and 33.1 nM, respectively. A biodistribution study in mice demonstrated low brain uptake of [ 18 F] 3 . Furthermore, bone radioactivity was stable at around 2% ID/g after injection, suggesting high tolerance to defluorination. Regarding metabolic stability, 70% of the compound was observed as the unchanged form at 30 minutes post injection in mouse plasma. A small animal PET study in mice showed that pretreatment with cyclosporine A had no effect on initial brain uptake of [ 18 F] 3 , suggesting low brain uptake of [ 18 F] 3 was not caused by the P‐glycoprotein–mediated efflux. While PET imaging using [ 18 F] 3 has a limitation with respect to neurodegenerative diseases, further studies evaluating its utility for certain cancers are worth evaluating." @default.
- W2997230048 created "2020-01-10" @default.
- W2997230048 creator A5015270336 @default.
- W2997230048 creator A5074027917 @default.
- W2997230048 creator A5083540706 @default.
- W2997230048 date "2020-01-09" @default.
- W2997230048 modified "2023-10-04" @default.
- W2997230048 title "Radiosynthesis and preliminary evaluation of an 18 F-labeled tubastatin A analog for PET imaging of histone deacetylase 6" @default.
- W2997230048 cites W1489237918 @default.
- W2997230048 cites W1875921292 @default.
- W2997230048 cites W1965212867 @default.
- W2997230048 cites W1970312374 @default.
- W2997230048 cites W1972005136 @default.
- W2997230048 cites W1978205433 @default.
- W2997230048 cites W1982555880 @default.
- W2997230048 cites W1989016584 @default.
- W2997230048 cites W1992027492 @default.
- W2997230048 cites W1993915316 @default.
- W2997230048 cites W1998106408 @default.
- W2997230048 cites W1998830506 @default.
- W2997230048 cites W2002698073 @default.
- W2997230048 cites W2003241187 @default.
- W2997230048 cites W2004627454 @default.
- W2997230048 cites W2020166595 @default.
- W2997230048 cites W2027171343 @default.
- W2997230048 cites W2038557487 @default.
- W2997230048 cites W2042224490 @default.
- W2997230048 cites W2044868753 @default.
- W2997230048 cites W2046316599 @default.
- W2997230048 cites W2053611887 @default.
- W2997230048 cites W2063078660 @default.
- W2997230048 cites W2064959533 @default.
- W2997230048 cites W2065437875 @default.
- W2997230048 cites W2071559249 @default.
- W2997230048 cites W2089695293 @default.
- W2997230048 cites W2090926709 @default.
- W2997230048 cites W2092476693 @default.
- W2997230048 cites W2093558543 @default.
- W2997230048 cites W2103312948 @default.
- W2997230048 cites W2107733280 @default.
- W2997230048 cites W2110787699 @default.
- W2997230048 cites W2119870623 @default.
- W2997230048 cites W2125568224 @default.
- W2997230048 cites W2162787110 @default.
- W2997230048 cites W2164106976 @default.
- W2997230048 cites W2195185668 @default.
- W2997230048 cites W2231435624 @default.
- W2997230048 cites W2258561766 @default.
- W2997230048 cites W2330753064 @default.
- W2997230048 cites W2347124890 @default.
- W2997230048 cites W2499381514 @default.
- W2997230048 cites W2499955277 @default.
- W2997230048 cites W2743399197 @default.
- W2997230048 cites W2753058178 @default.
- W2997230048 cites W2791835482 @default.
- W2997230048 cites W2892157567 @default.
- W2997230048 cites W2892723308 @default.
- W2997230048 cites W2903195053 @default.
- W2997230048 cites W2904008600 @default.
- W2997230048 cites W2920558115 @default.
- W2997230048 cites W2947146914 @default.
- W2997230048 cites W2951843350 @default.
- W2997230048 cites W4252686255 @default.
- W2997230048 doi "https://doi.org/10.1002/jlcr.3823" @default.
- W2997230048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31881107" @default.
- W2997230048 hasPublicationYear "2020" @default.
- W2997230048 type Work @default.
- W2997230048 sameAs 2997230048 @default.
- W2997230048 citedByCount "4" @default.
- W2997230048 countsByYear W29972300482020 @default.
- W2997230048 countsByYear W29972300482021 @default.
- W2997230048 countsByYear W29972300482022 @default.
- W2997230048 countsByYear W29972300482023 @default.
- W2997230048 crossrefType "journal-article" @default.
- W2997230048 hasAuthorship W2997230048A5015270336 @default.
- W2997230048 hasAuthorship W2997230048A5074027917 @default.
- W2997230048 hasAuthorship W2997230048A5083540706 @default.
- W2997230048 hasBestOaLocation W29972300481 @default.
- W2997230048 hasConcept C104317684 @default.
- W2997230048 hasConcept C177322064 @default.
- W2997230048 hasConcept C185592680 @default.
- W2997230048 hasConcept C202751555 @default.
- W2997230048 hasConcept C23681527 @default.
- W2997230048 hasConcept C2775842073 @default.
- W2997230048 hasConcept C2776262904 @default.
- W2997230048 hasConcept C2776970183 @default.
- W2997230048 hasConcept C2777807558 @default.
- W2997230048 hasConcept C2778305200 @default.
- W2997230048 hasConcept C2989005 @default.
- W2997230048 hasConcept C3017724952 @default.
- W2997230048 hasConcept C502942594 @default.
- W2997230048 hasConcept C55493867 @default.
- W2997230048 hasConcept C64927066 @default.
- W2997230048 hasConcept C71924100 @default.
- W2997230048 hasConcept C85240754 @default.
- W2997230048 hasConcept C86803240 @default.
- W2997230048 hasConceptScore W2997230048C104317684 @default.
- W2997230048 hasConceptScore W2997230048C177322064 @default.