FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997257906> ?p ?o ?g. }

• W2997257906 endingPage "677" @default.
• W2997257906 startingPage "669" @default.
• W2997257906 abstract "Overexpression of the mesenchymal-epithelial transition (MET) receptor, a receptor tyrosine kinase, can propel the growth of cancer cells and portends poor prognoses for patients with lung cancer. Evaluation of MET by immunohistochemistry is challenging, with MET protein overexpression varying from 20% to 80% between lung cancer cohorts. Clinical trials using MET protein expression to select patients have also reported a wide range of positivity rates and outcomes.To overcome this variability, the Lung Cancer Mutation Consortium Pathologist Panel endeavored to standardize the evaluation of MET protein expression with Round Robin conferences. This panel used randomly selected Aperio-scanned formalin-fixed paraffin-embedded lung cancer specimens stained by MET immunohistochemistry for the Lung Cancer Mutation Consortium 2.0 study (N=838). Seven pathologists in separate laboratories scored images of 5 initial cases and 2 subsequent rounds of 39 cases. The pathologists' scores were compared for consistency using the intraclass correlation coefficient. Issues affecting reproducibility were discussed in Round Robin conferences between rounds, and steps were taken to improve scoring consistency, such as sharing reference materials and example images.The overall group intraclass correlation coefficient comparing the consistency of scoring improved from 0.50 (95% confidence interval, 0.37-0.64) for the first scoring round to 0.74 (95% confidence interval, 0.64-0.83) for the second round.We found that the consistency of MET immunohistochemistry scoring is improved by continuous training and communication between pathologists." @default.
• W2997257906 created "2020-01-10" @default.
• W2997257906 creator A5003098673 @default.
• W2997257906 creator A5010278316 @default.
• W2997257906 creator A5013004380 @default.
• W2997257906 creator A5023971012 @default.
• W2997257906 creator A5024045160 @default.
• W2997257906 creator A5024457228 @default.
• W2997257906 creator A5025850464 @default.
• W2997257906 creator A5028085268 @default.
• W2997257906 creator A5033688721 @default.
• W2997257906 creator A5037786634 @default.
• W2997257906 creator A5039791495 @default.
• W2997257906 creator A5044340098 @default.
• W2997257906 creator A5061602647 @default.
• W2997257906 creator A5061791607 @default.
• W2997257906 creator A5064494204 @default.
• W2997257906 creator A5067028141 @default.
• W2997257906 creator A5071670695 @default.
• W2997257906 creator A5071851332 @default.
• W2997257906 creator A5072389805 @default.
• W2997257906 creator A5076266669 @default.
• W2997257906 creator A5082372978 @default.
• W2997257906 creator A5090956629 @default.
• W2997257906 date "2019-12-05" @default.
• W2997257906 modified "2023-10-18" @default.
• W2997257906 title "Round Robin Evaluation of MET Protein Expression in Lung Adenocarcinomas Improves Interobserver Concordance" @default.
• W2997257906 cites W1630530844 @default.
• W2997257906 cites W1968319149 @default.
• W2997257906 cites W1998971866 @default.
• W2997257906 cites W2009775937 @default.
• W2997257906 cites W2014230197 @default.
• W2997257906 cites W2055080028 @default.
• W2997257906 cites W2061704066 @default.
• W2997257906 cites W208286941 @default.
• W2997257906 cites W2087390525 @default.
• W2997257906 cites W2101581271 @default.
• W2997257906 cites W2130837590 @default.
• W2997257906 cites W2134107679 @default.
• W2997257906 cites W2140933230 @default.
• W2997257906 cites W2146137201 @default.
• W2997257906 cites W2159426719 @default.
• W2997257906 cites W2159741561 @default.
• W2997257906 cites W2160212814 @default.
• W2997257906 cites W2160725767 @default.
• W2997257906 cites W2169624569 @default.
• W2997257906 cites W2191995810 @default.
• W2997257906 cites W2230948985 @default.
• W2997257906 cites W2253815799 @default.
• W2997257906 cites W2276488517 @default.
• W2997257906 cites W2466657922 @default.
• W2997257906 cites W2504472048 @default.
• W2997257906 cites W2511032361 @default.
• W2997257906 cites W2549863932 @default.
• W2997257906 cites W2562169753 @default.
• W2997257906 cites W2597922927 @default.
• W2997257906 cites W2604488177 @default.
• W2997257906 cites W2765258454 @default.
• W2997257906 cites W2775798067 @default.
• W2997257906 cites W2792961879 @default.
• W2997257906 cites W2793975931 @default.
• W2997257906 cites W2799310318 @default.
• W2997257906 cites W2901863663 @default.
• W2997257906 cites W2902262211 @default.
• W2997257906 cites W2905009799 @default.
• W2997257906 cites W2916385204 @default.
• W2997257906 cites W2949648625 @default.
• W2997257906 cites W2964004560 @default.
• W2997257906 doi "https://doi.org/10.1097/pai.0000000000000810" @default.
• W2997257906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7242128" @default.
• W2997257906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31876606" @default.
• W2997257906 hasPublicationYear "2019" @default.
• W2997257906 type Work @default.
• W2997257906 sameAs 2997257906 @default.
• W2997257906 citedByCount "3" @default.
• W2997257906 countsByYear W29972579062021 @default.
• W2997257906 countsByYear W29972579062023 @default.
• W2997257906 crossrefType "journal-article" @default.
• W2997257906 hasAuthorship W2997257906A5003098673 @default.
• W2997257906 hasAuthorship W2997257906A5010278316 @default.
• W2997257906 hasAuthorship W2997257906A5013004380 @default.
• W2997257906 hasAuthorship W2997257906A5023971012 @default.
• W2997257906 hasAuthorship W2997257906A5024045160 @default.
• W2997257906 hasAuthorship W2997257906A5024457228 @default.
• W2997257906 hasAuthorship W2997257906A5025850464 @default.
• W2997257906 hasAuthorship W2997257906A5028085268 @default.
• W2997257906 hasAuthorship W2997257906A5033688721 @default.
• W2997257906 hasAuthorship W2997257906A5037786634 @default.
• W2997257906 hasAuthorship W2997257906A5039791495 @default.
• W2997257906 hasAuthorship W2997257906A5044340098 @default.
• W2997257906 hasAuthorship W2997257906A5061602647 @default.
• W2997257906 hasAuthorship W2997257906A5061791607 @default.
• W2997257906 hasAuthorship W2997257906A5064494204 @default.
• W2997257906 hasAuthorship W2997257906A5067028141 @default.
• W2997257906 hasAuthorship W2997257906A5071670695 @default.
• W2997257906 hasAuthorship W2997257906A5071851332 @default.
• W2997257906 hasAuthorship W2997257906A5072389805 @default.
• W2997257906 hasAuthorship W2997257906A5076266669 @default.

• next