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- W2997264294 abstract "CD155 (PVR/necl5/Tage4), a member of the nectin-like family of adhesion molecules, is highly upregulated on tumor cells across multiple cancer types and has been associated with worse patient outcomes. In addition to well described cell-intrinsic roles promoting tumor progression and metastasis, CD155 has now been implicated in immune regulation. The role of CD155 as a potent immune ligand with diverse cell-extrinsic functions is now being defined. CD155 signaling to immune cells is mediated through interactions with the co-stimulatory immune receptor CD226 (DNAM-1) and the inhibitory checkpoint receptors TIGIT and CD96, which are differentially regulated at the cell surface on T cells and NK cells. The integration of signals from CD155 cognate receptors modifies the activity of tumor-infiltrating lymphocytes in a context-dependent manner, making CD155 an attractive target for immune-oncology. Preclinical studies suggest that targeting this axis can improve immune-mediated tumor control, particularly when combined with existing anti-PD-1 checkpoint therapies. In this review, we discuss the roles of CD155 on host and tumor cells in controlling tumor progression and discuss the possibility of targeting CD155 for cancer therapy." @default.
- W2997264294 created "2020-01-10" @default.
- W2997264294 creator A5030018577 @default.
- W2997264294 creator A5054386807 @default.
- W2997264294 creator A5061575707 @default.
- W2997264294 creator A5077460838 @default.
- W2997264294 date "2020-10-01" @default.
- W2997264294 modified "2023-10-17" @default.
- W2997264294 title "Tumor intrinsic and extrinsic immune functions of CD155" @default.
- W2997264294 cites W1481317976 @default.
- W2997264294 cites W1552754679 @default.
- W2997264294 cites W1574100082 @default.
- W2997264294 cites W1634951127 @default.
- W2997264294 cites W1775356736 @default.
- W2997264294 cites W1853094319 @default.
- W2997264294 cites W1863751964 @default.
- W2997264294 cites W1965386810 @default.
- W2997264294 cites W1972472884 @default.
- W2997264294 cites W1976152961 @default.
- W2997264294 cites W1980311792 @default.
- W2997264294 cites W1983812780 @default.
- W2997264294 cites W1987165863 @default.
- W2997264294 cites W1988718810 @default.
- W2997264294 cites W1990826761 @default.
- W2997264294 cites W2004191344 @default.
- W2997264294 cites W2004630197 @default.
- W2997264294 cites W2007825988 @default.
- W2997264294 cites W2022465587 @default.
- W2997264294 cites W2023283620 @default.
- W2997264294 cites W2029399624 @default.
- W2997264294 cites W2039148818 @default.
- W2997264294 cites W2050216826 @default.
- W2997264294 cites W2050457398 @default.
- W2997264294 cites W2057893793 @default.
- W2997264294 cites W2058817587 @default.
- W2997264294 cites W2066157119 @default.
- W2997264294 cites W2072598572 @default.
- W2997264294 cites W2073303594 @default.
- W2997264294 cites W2076789092 @default.
- W2997264294 cites W2081118119 @default.
- W2997264294 cites W2082252308 @default.
- W2997264294 cites W2086808694 @default.
- W2997264294 cites W2092019188 @default.
- W2997264294 cites W2092207202 @default.
- W2997264294 cites W2100376107 @default.
- W2997264294 cites W2103028860 @default.
- W2997264294 cites W2104192569 @default.
- W2997264294 cites W2105440238 @default.
- W2997264294 cites W2116628473 @default.
- W2997264294 cites W2123635642 @default.
- W2997264294 cites W2142169541 @default.
- W2997264294 cites W2142256141 @default.
- W2997264294 cites W2144761208 @default.
- W2997264294 cites W2149312162 @default.
- W2997264294 cites W2152897456 @default.
- W2997264294 cites W2159543099 @default.
- W2997264294 cites W2159896657 @default.
- W2997264294 cites W2160352261 @default.
- W2997264294 cites W2166781388 @default.
- W2997264294 cites W2168459600 @default.
- W2997264294 cites W2169810189 @default.
- W2997264294 cites W2203408849 @default.
- W2997264294 cites W2225828937 @default.
- W2997264294 cites W2254024193 @default.
- W2997264294 cites W2261307795 @default.
- W2997264294 cites W2321831128 @default.
- W2997264294 cites W2332535881 @default.
- W2997264294 cites W2334486829 @default.
- W2997264294 cites W2592785733 @default.
- W2997264294 cites W2610509384 @default.
- W2997264294 cites W2611919322 @default.
- W2997264294 cites W2615188404 @default.
- W2997264294 cites W2621450645 @default.
- W2997264294 cites W2724966337 @default.
- W2997264294 cites W2737469573 @default.
- W2997264294 cites W2740980780 @default.
- W2997264294 cites W2751553129 @default.
- W2997264294 cites W2782698921 @default.
- W2997264294 cites W2793843330 @default.
- W2997264294 cites W2797309423 @default.
- W2997264294 cites W2797429263 @default.
- W2997264294 cites W2801787974 @default.
- W2997264294 cites W2806726370 @default.
- W2997264294 cites W2808601843 @default.
- W2997264294 cites W2879746793 @default.
- W2997264294 cites W2883223052 @default.
- W2997264294 cites W2887577080 @default.
- W2997264294 cites W2890227972 @default.
- W2997264294 cites W2892839743 @default.
- W2997264294 cites W2898408624 @default.
- W2997264294 cites W2905064003 @default.
- W2997264294 cites W2925007462 @default.
- W2997264294 cites W2940599050 @default.
- W2997264294 cites W2950277329 @default.
- W2997264294 cites W2950413690 @default.
- W2997264294 cites W2951598503 @default.
- W2997264294 cites W2952815301 @default.
- W2997264294 cites W2957565477 @default.