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- W2997279546 abstract "Orexins/hypocretins and their receptors (OXRs) are ubiquitously distributed throughout the nervous system and peripheral tissues. Recently, various reports have indicated that orexins play regulatory roles in numerous physiological processes involved in obesity, energy homeostasis, sleep-wake cycle, analgesia, alcoholism, learning, and memory. This review aims to outline recent progress in the research and development of orexins used in biochemical signaling pathways, secretion pathways, and the regulation of energy metabolism/adipose tissue development. Orexins regulate a variety of physiological functions in the body by activating phospholipase C/protein kinase C and AC/cAMP/PKA pathways, through receptors coupled to Gq and Gi/Gs, respectively. The secretion of orexins is modulated by blood glucose, blood lipids, hormones, and neuropeptides. Orexins have critical functions in energy metabolism, regulating both feeding behavior and energy expenditure. Increasing the sensitivity of orexin-coupled hypothalamic neurons concurrently enhances spontaneous physical activity, non-exercise activity thermogenesis, white adipose tissue lipolysis, and brown adipose tissue thermogenesis. With this comprehensive review of the current literature on the subject, we hope to provide an integrated perspective for the prevention/treatment of obesity." @default.
- W2997279546 created "2020-01-10" @default.
- W2997279546 creator A5009304661 @default.
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- W2997279546 creator A5080716277 @default.
- W2997279546 date "2019-12-27" @default.
- W2997279546 modified "2023-10-15" @default.
- W2997279546 title "Physiological Implications of Orexins/Hypocretins on Energy Metabolism and Adipose Tissue Development" @default.
- W2997279546 cites W1253179 @default.
- W2997279546 cites W1254015217 @default.
- W2997279546 cites W1501722970 @default.
- W2997279546 cites W1879258289 @default.
- W2997279546 cites W1900806505 @default.
- W2997279546 cites W1955207787 @default.
- W2997279546 cites W1969261691 @default.
- W2997279546 cites W1970545820 @default.
- W2997279546 cites W1971388525 @default.
- W2997279546 cites W1975123933 @default.
- W2997279546 cites W1975168865 @default.
- W2997279546 cites W1975368889 @default.
- W2997279546 cites W1975983146 @default.
- W2997279546 cites W1976710483 @default.
- W2997279546 cites W1976820875 @default.
- W2997279546 cites W1979634443 @default.
- W2997279546 cites W1981681682 @default.
- W2997279546 cites W1982941171 @default.
- W2997279546 cites W1982962897 @default.
- W2997279546 cites W1983445020 @default.
- W2997279546 cites W1990322878 @default.
- W2997279546 cites W1990331613 @default.
- W2997279546 cites W1992136497 @default.
- W2997279546 cites W1992895646 @default.
- W2997279546 cites W1993493229 @default.
- W2997279546 cites W1999433238 @default.
- W2997279546 cites W2010690836 @default.
- W2997279546 cites W2013655437 @default.
- W2997279546 cites W2016536597 @default.
- W2997279546 cites W2018594569 @default.
- W2997279546 cites W2019910740 @default.
- W2997279546 cites W2026363549 @default.
- W2997279546 cites W2027740042 @default.
- W2997279546 cites W2035053157 @default.
- W2997279546 cites W2036325467 @default.
- W2997279546 cites W2041185300 @default.
- W2997279546 cites W2041731336 @default.
- W2997279546 cites W2043214886 @default.
- W2997279546 cites W2043875236 @default.
- W2997279546 cites W2045033987 @default.
- W2997279546 cites W2047820724 @default.
- W2997279546 cites W2051726070 @default.
- W2997279546 cites W2052972724 @default.
- W2997279546 cites W2057063716 @default.
- W2997279546 cites W2058910991 @default.
- W2997279546 cites W2064990026 @default.
- W2997279546 cites W2065259467 @default.
- W2997279546 cites W2069036367 @default.
- W2997279546 cites W2069066834 @default.
- W2997279546 cites W2073650130 @default.
- W2997279546 cites W2074104060 @default.
- W2997279546 cites W2081911304 @default.
- W2997279546 cites W2082775813 @default.
- W2997279546 cites W2086507755 @default.
- W2997279546 cites W2102220170 @default.
- W2997279546 cites W2107201710 @default.
- W2997279546 cites W2121147520 @default.
- W2997279546 cites W2122782956 @default.
- W2997279546 cites W2125667577 @default.
- W2997279546 cites W2140706800 @default.
- W2997279546 cites W2141139112 @default.
- W2997279546 cites W2143609607 @default.
- W2997279546 cites W2146736957 @default.
- W2997279546 cites W2146798664 @default.
- W2997279546 cites W2152211310 @default.
- W2997279546 cites W2154434397 @default.
- W2997279546 cites W2157277051 @default.
- W2997279546 cites W2159953069 @default.
- W2997279546 cites W2163325983 @default.
- W2997279546 cites W2170390435 @default.
- W2997279546 cites W2171223091 @default.
- W2997279546 cites W2171376440 @default.
- W2997279546 cites W2515318044 @default.
- W2997279546 cites W2520995681 @default.
- W2997279546 cites W2585927828 @default.
- W2997279546 cites W2594293479 @default.
- W2997279546 cites W2599766179 @default.
- W2997279546 cites W2605643675 @default.
- W2997279546 cites W2606600532 @default.
- W2997279546 cites W2742528889 @default.
- W2997279546 cites W2781950671 @default.
- W2997279546 cites W2789882758 @default.
- W2997279546 cites W2801623726 @default.
- W2997279546 cites W2804120879 @default.