FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997292208> ?p ?o ?g. }

• W2997292208 endingPage "131" @default.
• W2997292208 startingPage "131" @default.
• W2997292208 abstract "The divalent cation-selective channel transient receptor potential melastatin 7 (TRPM7) channel was shown to affect the proliferation of some types of cancer cell. However, the function of TRPM7 in the viability of breast cancer cells remains unclear. Here we show that TRPM inhibitors suppressed the viability of TRPM7-expressing breast cancer cells. We first demonstrated that the TRPM7 inhibitors 2-aminoethyl diphenylborinate (2-APB), ginsenoside Rd (Gin Rd), and waixenicin A preferentially suppressed the viability of human embryonic kidney HEK293 overexpressing TRPM7 (HEK-M7) cells over wildtype HEK293 (WT-HEK). Next, we confirmed the effects of 2-APB on the TRPM7 channel functions by whole-cell currents and divalent cation influx. The inhibition of the viability of HEK-M7 cells by 2-APB was not mediated by the increase in cell death but by the interruption of the cell cycle. Similar to HEK-M7 cells, the viability of TRPM7-expressing human breast cancer MDA-MB-231, AU565, and T47D cells were also suppressed by 2-APB by arresting the cell cycle in the S phase. Furthermore, in a novel TRPM7 knock-out MDA-MB-231 (KO-231) cell line, decreased divalent influx and reduced proliferation were observed compared to the wildtype MDA-MB-231 cells. 2-APB and Gin Rd preferentially suppressed the viability of wildtype MDA-MB-231 cells over KO-231 by affecting the cell cycle in wildtype but not KO-231 cells. Our results suggest that TRPM7 regulates the cell cycle of breast cancers and is a potential therapeutic target." @default.
• W2997292208 created "2020-01-10" @default.
• W2997292208 creator A5000529658 @default.
• W2997292208 creator A5002052225 @default.
• W2997292208 creator A5074147148 @default.
• W2997292208 date "2020-01-04" @default.
• W2997292208 modified "2023-09-30" @default.
• W2997292208 title "The Role of Transient Receptor Potential Melastatin 7 (TRPM7) in Cell Viability: A Potential Target to Suppress Breast Cancer Cell Cycle" @default.
• W2997292208 cites W1559892880 @default.
• W2997292208 cites W1874327812 @default.
• W2997292208 cites W1930917734 @default.
• W2997292208 cites W1974673111 @default.
• W2997292208 cites W1982872797 @default.
• W2997292208 cites W2012034410 @default.
• W2997292208 cites W2021569813 @default.
• W2997292208 cites W2036145275 @default.
• W2997292208 cites W2038365446 @default.
• W2997292208 cites W2039527919 @default.
• W2997292208 cites W2040664792 @default.
• W2997292208 cites W2041690080 @default.
• W2997292208 cites W2046372462 @default.
• W2997292208 cites W2052765538 @default.
• W2997292208 cites W2056428844 @default.
• W2997292208 cites W2066581734 @default.
• W2997292208 cites W2075802597 @default.
• W2997292208 cites W2083897778 @default.
• W2997292208 cites W2084534079 @default.
• W2997292208 cites W2113304856 @default.
• W2997292208 cites W2120018864 @default.
• W2997292208 cites W2126283502 @default.
• W2997292208 cites W2127012396 @default.
• W2997292208 cites W2130485330 @default.
• W2997292208 cites W2141091145 @default.
• W2997292208 cites W2142739240 @default.
• W2997292208 cites W2163323412 @default.
• W2997292208 cites W2166073081 @default.
• W2997292208 cites W2198581563 @default.
• W2997292208 cites W2414831439 @default.
• W2997292208 cites W2520217397 @default.
• W2997292208 cites W2571343712 @default.
• W2997292208 cites W2581018228 @default.
• W2997292208 cites W2604748777 @default.
• W2997292208 cites W2607129810 @default.
• W2997292208 cites W2662170517 @default.
• W2997292208 cites W2745239389 @default.
• W2997292208 cites W2747178568 @default.
• W2997292208 cites W2781525129 @default.
• W2997292208 cites W2806670887 @default.
• W2997292208 cites W2807848703 @default.
• W2997292208 cites W2894993444 @default.
• W2997292208 cites W2937750813 @default.
• W2997292208 cites W6853850 @default.
• W2997292208 doi "https://doi.org/10.3390/cancers12010131" @default.
• W2997292208 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7016641" @default.
• W2997292208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31947967" @default.
• W2997292208 hasPublicationYear "2020" @default.
• W2997292208 type Work @default.
• W2997292208 sameAs 2997292208 @default.
• W2997292208 citedByCount "38" @default.
• W2997292208 countsByYear W29972922082020 @default.
• W2997292208 countsByYear W29972922082021 @default.
• W2997292208 countsByYear W29972922082022 @default.
• W2997292208 countsByYear W29972922082023 @default.
• W2997292208 crossrefType "journal-article" @default.
• W2997292208 hasAuthorship W2997292208A5000529658 @default.
• W2997292208 hasAuthorship W2997292208A5002052225 @default.
• W2997292208 hasAuthorship W2997292208A5074147148 @default.
• W2997292208 hasBestOaLocation W29972922081 @default.
• W2997292208 hasConcept C104317684 @default.
• W2997292208 hasConcept C105696609 @default.
• W2997292208 hasConcept C143065580 @default.
• W2997292208 hasConcept C1491633281 @default.
• W2997292208 hasConcept C153911025 @default.
• W2997292208 hasConcept C155164980 @default.
• W2997292208 hasConcept C170493617 @default.
• W2997292208 hasConcept C174510640 @default.
• W2997292208 hasConcept C185592680 @default.
• W2997292208 hasConcept C207583985 @default.
• W2997292208 hasConcept C29537977 @default.
• W2997292208 hasConcept C502942594 @default.
• W2997292208 hasConcept C53227056 @default.
• W2997292208 hasConcept C53467394 @default.
• W2997292208 hasConcept C54355233 @default.
• W2997292208 hasConcept C55493867 @default.
• W2997292208 hasConcept C62112901 @default.
• W2997292208 hasConcept C81885089 @default.
• W2997292208 hasConcept C86803240 @default.
• W2997292208 hasConcept C95444343 @default.
• W2997292208 hasConceptScore W2997292208C104317684 @default.
• W2997292208 hasConceptScore W2997292208C105696609 @default.
• W2997292208 hasConceptScore W2997292208C143065580 @default.
• W2997292208 hasConceptScore W2997292208C1491633281 @default.
• W2997292208 hasConceptScore W2997292208C153911025 @default.
• W2997292208 hasConceptScore W2997292208C155164980 @default.
• W2997292208 hasConceptScore W2997292208C170493617 @default.
• W2997292208 hasConceptScore W2997292208C174510640 @default.
• W2997292208 hasConceptScore W2997292208C185592680 @default.
• W2997292208 hasConceptScore W2997292208C207583985 @default.

• next