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- W2997300931 abstract "ObjectiveThe aim was to evaluate early changes of intraocular pressure (IOP) after repeated ranibizumab (Lucentis) injection.BackgroundRanibizumab is widely used in the treatment of macular edema and choroidal neovascularization. Screening should be frequently done to avoid its adverse effect.Materials and methodsA prospective noncomparative case series study was conducted at Menoufia and Kalawoon hospitals, where patients were subjected to intravitreal injection of ranibizumab (Lucentis) for early IOP changes. IOP was measured with a Goldman tonometer before injection, after 30 min, after 1 day, and after 1 week of injection.ResultsAt every time of injection, there was a highly significant difference in IOP measured at 30 min after injection (P < 0.001). However, there was no significant difference measured after 1 day (P = 0.91) and after 1 week of injection (P = 0.56). In repeated intravitreal ranibizumab injection comparison of preoperative, 30 min, 1 day, and 1 week after injection correspondingly, we found no significant difference in IOP measured between first and second injection in preoperative, 30 min, 1 day, and 1 week after injection (P = 0.11, 0.36, 0.17, and 0.26, respectively). However, there was a significant difference in IOP measured between first and third injections regarding preoperative, 30 min, 1 day, and 1 week after injection (P = 0.3, 0.2, 0.1, and 0.3, respectively).ConclusionRanibizumab injected intravitreally causes a significant transient rise of IOP. The rise is transient for 24 h and normalizes after that." @default.
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- W2997300931 date "2019-01-01" @default.
- W2997300931 modified "2023-09-26" @default.
- W2997300931 title "Intraocular pressure changes after repeated ranibizumab injection" @default.
- W2997300931 doi "https://doi.org/10.4103/mmj.mmj_270_18" @default.
- W2997300931 hasPublicationYear "2019" @default.
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