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- W2997301310 endingPage "100925" @default.
- W2997301310 startingPage "100925" @default.
- W2997301310 abstract "The microbiota in the human gut are an important component of normal physiology that has co-evolved from the earliest multicellular organisms. Therefore, it is unsurprising that there is intimate crosstalk between the microbial world in the gut and the host. Genome regulation through microbiota-host interactions not only affects the host's immunity, but also metabolic health and resilience against cancer. Chromatin dynamics of the host epithelium involving histone modifications and other facets of the epigenetic machinery play an important role in this process.This review discusses recent findings relevant to how chromatin dynamics shape the crosstalk between the microbiota and its host, with a special focus on the role of histone modifications.Host-microbiome interactions are important evolutionary drivers and are thus expected to be hardwired into and mould the epigenetic machinery in multicellular organisms. Microbial-derived short-chain fatty acids (SCFA) are dominant determinants of microbiome-host interactions, and the inhibition of histone deacetylases (HDACs) by SCFA is a key mechanism in this process. The discovery of alternative histone acylations, such as crotonylation, in addition to the canonical histone acetylation reveals a new layer of complexity in this crosstalk." @default.
- W2997301310 created "2020-01-10" @default.
- W2997301310 creator A5036301404 @default.
- W2997301310 creator A5085327068 @default.
- W2997301310 date "2020-08-01" @default.
- W2997301310 modified "2023-10-10" @default.
- W2997301310 title "Chromatin dynamics and histone modifications in intestinal microbiota-host crosstalk" @default.
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