FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997316077> ?p ?o ?g. }

• W2997316077 abstract "Acebutolol HCl (ABL) is a selective β-adrenergic receptor blocking agent that is preferably administered by the oral route despite its low bioavailability (30-50%). The purpose of this study was to evaluate the effect of verapamil HCl (VER) [as P-glycoprotein inhibitor (P-gp)] on the intestinal absorption of ABL by comparing the changes in the absorption rate constant (kap) of ABL.In situ intestinal perfusion was conducted in healthy male Wistar albino rats to study the absorption phase of ABL. Eighteen rats were divided into three groups. The first group (the control group) was perfused with ABL alone (260 μg/mL). The second and third groups were perfused with ABL (260 μg/mL) in combination with VER at different concentrations (200 and 400 μg/mL, respectively). The analysis was performed using a simple, rapid, and validated spectroscopic method.The absorption study showed that kap of ABL in the first group was 0.47±0.045 h-1. In the third group kap increased 3-fold (1.37±0.031 h-1); however, the second group showed a statistically insignificant change in kap (0.39±0.076 h-1).The results revealed that VER at a concentration of 400 μg/mL has a pronounced effect on the absorption kinetics of ABL (increased kap). This could be linked to the inhibition of P-gp, which is considered a contributing factor in low bioavailability of ABL." @default.
• W2997316077 created "2020-01-10" @default.
• W2997316077 creator A5004161642 @default.
• W2997316077 creator A5026057351 @default.
• W2997316077 creator A5026923391 @default.
• W2997316077 creator A5055919139 @default.
• W2997316077 creator A5073855371 @default.
• W2997316077 creator A5085417368 @default.
• W2997316077 date "2020-12-01" @default.
• W2997316077 modified "2023-09-28" @default.
• W2997316077 title "<i>In Situ</i> Absorption Study of Acebutolol by Modulating P-glycoprotein with Verapamil in Rats" @default.
• W2997316077 cites W173786933 @default.
• W2997316077 cites W1967373133 @default.
• W2997316077 cites W1977470253 @default.
• W2997316077 cites W1986724044 @default.
• W2997316077 cites W2002619956 @default.
• W2997316077 cites W2006967678 @default.
• W2997316077 cites W2009169076 @default.
• W2997316077 cites W2020387582 @default.
• W2997316077 cites W2038660711 @default.
• W2997316077 cites W2061321840 @default.
• W2997316077 cites W2072922667 @default.
• W2997316077 cites W2073061907 @default.
• W2997316077 cites W2076433288 @default.
• W2997316077 cites W2079197876 @default.
• W2997316077 cites W2081213990 @default.
• W2997316077 cites W2091641102 @default.
• W2997316077 cites W2096523918 @default.
• W2997316077 cites W2119303634 @default.
• W2997316077 cites W2135760142 @default.
• W2997316077 cites W2230621190 @default.
• W2997316077 cites W2290466312 @default.
• W2997316077 cites W2325168223 @default.
• W2997316077 cites W308582299 @default.
• W2997316077 cites W5737657 @default.
• W2997316077 doi "https://doi.org/10.4274/tjps.galenos.2019.59862" @default.
• W2997316077 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7786063" @default.
• W2997316077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33389978" @default.
• W2997316077 hasPublicationYear "2020" @default.
• W2997316077 type Work @default.
• W2997316077 sameAs 2997316077 @default.
• W2997316077 citedByCount "0" @default.
• W2997316077 crossrefType "journal-article" @default.
• W2997316077 hasAuthorship W2997316077A5004161642 @default.
• W2997316077 hasAuthorship W2997316077A5026057351 @default.
• W2997316077 hasAuthorship W2997316077A5026923391 @default.
• W2997316077 hasAuthorship W2997316077A5055919139 @default.
• W2997316077 hasAuthorship W2997316077A5073855371 @default.
• W2997316077 hasAuthorship W2997316077A5085417368 @default.
• W2997316077 hasBestOaLocation W29973160771 @default.
• W2997316077 hasConcept C125287762 @default.
• W2997316077 hasConcept C126322002 @default.
• W2997316077 hasConcept C133936738 @default.
• W2997316077 hasConcept C146957229 @default.
• W2997316077 hasConcept C159985019 @default.
• W2997316077 hasConcept C178790620 @default.
• W2997316077 hasConcept C181389837 @default.
• W2997316077 hasConcept C185592680 @default.
• W2997316077 hasConcept C192562407 @default.
• W2997316077 hasConcept C2777022698 @default.
• W2997316077 hasConcept C2778707650 @default.
• W2997316077 hasConcept C501593827 @default.
• W2997316077 hasConcept C519063684 @default.
• W2997316077 hasConcept C55493867 @default.
• W2997316077 hasConcept C71924100 @default.
• W2997316077 hasConcept C98274493 @default.
• W2997316077 hasConceptScore W2997316077C125287762 @default.
• W2997316077 hasConceptScore W2997316077C126322002 @default.
• W2997316077 hasConceptScore W2997316077C133936738 @default.
• W2997316077 hasConceptScore W2997316077C146957229 @default.
• W2997316077 hasConceptScore W2997316077C159985019 @default.
• W2997316077 hasConceptScore W2997316077C178790620 @default.
• W2997316077 hasConceptScore W2997316077C181389837 @default.
• W2997316077 hasConceptScore W2997316077C185592680 @default.
• W2997316077 hasConceptScore W2997316077C192562407 @default.
• W2997316077 hasConceptScore W2997316077C2777022698 @default.
• W2997316077 hasConceptScore W2997316077C2778707650 @default.
• W2997316077 hasConceptScore W2997316077C501593827 @default.
• W2997316077 hasConceptScore W2997316077C519063684 @default.
• W2997316077 hasConceptScore W2997316077C55493867 @default.
• W2997316077 hasConceptScore W2997316077C71924100 @default.
• W2997316077 hasConceptScore W2997316077C98274493 @default.
• W2997316077 hasLocation W29973160771 @default.
• W2997316077 hasLocation W29973160772 @default.
• W2997316077 hasLocation W29973160773 @default.
• W2997316077 hasLocation W29973160774 @default.
• W2997316077 hasOpenAccess W2997316077 @default.
• W2997316077 hasPrimaryLocation W29973160771 @default.
• W2997316077 hasRelatedWork W10018554 @default.
• W2997316077 hasRelatedWork W10346456 @default.
• W2997316077 hasRelatedWork W10351103 @default.
• W2997316077 hasRelatedWork W11930179 @default.
• W2997316077 hasRelatedWork W2850926 @default.
• W2997316077 hasRelatedWork W4089902 @default.
• W2997316077 hasRelatedWork W509271 @default.
• W2997316077 hasRelatedWork W5737657 @default.
• W2997316077 hasRelatedWork W8980483 @default.
• W2997316077 hasRelatedWork W9354869 @default.
• W2997316077 isParatext "false" @default.
• W2997316077 isRetracted "false" @default.

• next