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• W2997334677 abstract "Abstract Background Multiple alignments of mammalian genomes have been the basis of many comparative genomic studies aiming at annotating genes, detecting regions under evolutionary constraint, and studying genome evolution. A key factor that affects the power of comparative analyses is the number of species included in a genome alignment. Results To utilize the increased number of sequenced genomes and to provide an accessible resource for genomic studies, we generated a mammalian genome alignment comprising 120 species. We used this alignment and the CESAR method to provide protein-coding gene annotations for 119 non-human mammals. Furthermore, we illustrate the utility of this alignment by 2 exemplary analyses. First, we quantified how variable ultraconserved elements (UCEs) are among placental mammals. Leveraging the high taxonomic coverage in our alignment, we estimate that UCEs contain on average 4.7%–15.6% variable alignment columns. Furthermore, we show that the center regions of UCEs are generally most constrained. Second, we identified enhancer sequences that are only conserved in placental mammals. We found that these enhancers are significantly associated with placenta-related genes, suggesting that some of these enhancers may be involved in the evolution of placental mammal-specific aspects of the placenta. Conclusion The 120-mammal alignment and all other data are available for analysis and visualization in a genome browser at https://genome-public.pks.mpg.de/and for download at https://bds.mpi-cbg.de/hillerlab/120MammalAlignment/." @default.
• W2997334677 created "2020-01-10" @default.
• W2997334677 creator A5034973395 @default.
• W2997334677 creator A5041994630 @default.
• W2997334677 date "2020-01-01" @default.
• W2997334677 modified "2023-10-03" @default.
• W2997334677 title "A genome alignment of 120 mammals highlights ultraconserved element variability and placenta-associated enhancers" @default.
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• W2997334677 doi "https://doi.org/10.1093/gigascience/giz159" @default.
• W2997334677 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6941714" @default.
• W2997334677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31899510" @default.
• W2997334677 hasPublicationYear "2020" @default.
• W2997334677 type Work @default.
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• W2997334677 citedByCount "23" @default.

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