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- W2997357318 abstract "Background: Resection is the only curative treatment for patients with metastatic colorectal cancer (mCRC). Over half of patients undergoing liver resection will develop recurrent disease, but a second liver resection may offer the possibility of prolonged survival in some patients. Methods: Prospective data were obtained from 2006 to 2016. Patients having 2 or more liver resections for mCRC and 12 months of follow-up were included. Cases with two-stage resections or extra-hepatic disease were excluded. Standard pre-operative staging comprised of a CT scan of chest, abdomen and pelvis and a liver MRI scan. Post-operative surveillance was with 6 monthly CT and serum CEA for 2 years, and then annually. Operative outcomes, disease recurrence and survival were analysed. Results: 899 liver resections were carried out over 10 years. 62 patients underwent 1 or more re-resection for mCRC. 3 patients were unresectable at laparotomy. In total 70 redo liver resections were performed on 62 patients. Mortality was 1.4% (1/70) and all-cause morbidity was 35%. Median survival from the date of first re-resection was 42 months (95% CI 32 – 71 months), with a recurrence rate of 66% (41/62) and estimated 5-yr survival of 37%. Conclusion: Repeated liver resection is an aggressive but safe strategy for dealing with recurrent CRLM. Recurrence rates of 37% and 60% at 1 and 2 years respectively justify intense surveillance. Overall survival is comparable with single resection series." @default.
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- W2997357318 date "2019-01-01" @default.
- W2997357318 modified "2023-09-27" @default.
- W2997357318 title "Ten year experience of re-resection of recurrent liver-only colorectal metastases" @default.
- W2997357318 doi "https://doi.org/10.1016/j.hpb.2019.10.420" @default.
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