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- W2997357396 abstract "Intra-amniotic sludge (IAS), a sonographic finding of particulate matter in close proximity to the cervical os, has been implicated as a risk factor for preterm delivery and poor neonatal outcomes. Studies dedicated to identification of risk factors for the development of IAS are sparse. Our objective is to characterize risk factors for the development of IAS in women undergoing exam or ultrasound indicated cerclage. We performed a hospital-based, case-control study of women who underwent ultrasound or exam indicated cerclage over 3 years. Women with multiple gestation, cerclage placement at an outside institution, or missing data were excluded. The presence or absence of IAS was confirmed by review of sonographic images. Women with evidence of IAS served as cases, while those without served as controls. Risk factors for development of IAS and neonatal outcomes were compared in the two groups. We fit a multivariable logistic regression model to identify independent risk factors for presence of IAS. Of the 111 women included, 33 (29.7%) had sonographic evidence of IAS. The likelihood of developing IAS was similar between patients with exam and ultrasound indicated cerclage (OR 0.64 95% CI 0.28, 1.48). There was no statistically significant difference in maternal race, ethnicity, insurance type, marital status, parity, drug/alcohol/cigarette use, BMI, history of preterm birth, cervical length and cervical dilation prior to cerclage placement in patients with IAS and those without (Table 1). These findings were reiterated in a multivariable regression analysis, where no independent risk factor was identified (Table 2). Neonatal outcomes, including birth weight, seizures, respiratory distress syndrome, intraventricular hemorrhage, sepsis, and demise were additionally similar between the groups. Our study shows that there are no significant risk factors associated with development of IAS among patients with exam or ultrasound indicated cerclage. The presence of IAS is also not predictive of adverse neonatal outcomes. A larger study is needed to verify our findings.View Large Image Figure ViewerDownload Hi-res image Download (PPT)" @default.
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- W2997357396 date "2020-01-01" @default.
- W2997357396 modified "2023-10-18" @default.
- W2997357396 title "974: Risk factors for the development of Intra-Amniotic Sludge" @default.
- W2997357396 doi "https://doi.org/10.1016/j.ajog.2019.11.985" @default.
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