Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997372244> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2997372244 abstract "Insulin synthesis in pancreatic β-cells is initiated as preproinsulin. Prevailing glucose concentrations, which oscillate pre- and postprandially, exert major dynamic variation in preproinsulin biosynthesis. Accompanying upregulated translation of the insulin precursor includes elements of the endoplasmic reticulum (ER) translocation apparatus linked to successful orientation of the signal peptide, translocation and signal peptide cleavage of preproinsulin-all of which are necessary to initiate the pathway of proper proinsulin folding. Evolutionary pressures on the primary structure of proinsulin itself have preserved the efficiency of folding (foldability), and remarkably, these evolutionary pressures are distinct from those protecting the ultimate biological activity of insulin. Proinsulin foldability is manifest in the ER, in which the local environment is designed to assist in the overall load of proinsulin folding and to favour its disulphide bond formation (while limiting misfolding), all of which is closely tuned to ER stress response pathways that have complex (beneficial, as well as potentially damaging) effects on pancreatic β-cells. Proinsulin misfolding may occur as a consequence of exuberant proinsulin biosynthetic load in the ER, proinsulin coding sequence mutations, or genetic predispositions that lead to an altered ER folding environment. Proinsulin misfolding is a phenotype that is very much linked to deficient insulin production and diabetes, as is seen in a variety of contexts: rodent models bearing proinsulin-misfolding mutants, human patients with Mutant INS-gene-induced Diabetes of Youth (MIDY), animal models and human patients bearing mutations in critical ER resident proteins, and, quite possibly, in more common variety type 2 diabetes." @default.
- W2997372244 created "2020-01-10" @default.
- W2997372244 creator A5013425190 @default.
- W2997372244 creator A5015059732 @default.
- W2997372244 creator A5015378855 @default.
- W2997372244 creator A5026241760 @default.
- W2997372244 creator A5033062448 @default.
- W2997372244 creator A5043547564 @default.
- W2997372244 creator A5063746171 @default.
- W2997372244 creator A5072170846 @default.
- W2997372244 creator A5076264613 @default.
- W2997372244 date "2018-09-01" @default.
- W2997372244 modified "2023-09-26" @default.
- W2997372244 title "Biosynthesis, structure, and folding of the insulin precursor protein" @default.
- W2997372244 hasPublicationYear "2018" @default.
- W2997372244 type Work @default.
- W2997372244 sameAs 2997372244 @default.
- W2997372244 citedByCount "0" @default.
- W2997372244 crossrefType "journal-article" @default.
- W2997372244 hasAuthorship W2997372244A5013425190 @default.
- W2997372244 hasAuthorship W2997372244A5015059732 @default.
- W2997372244 hasAuthorship W2997372244A5015378855 @default.
- W2997372244 hasAuthorship W2997372244A5026241760 @default.
- W2997372244 hasAuthorship W2997372244A5033062448 @default.
- W2997372244 hasAuthorship W2997372244A5043547564 @default.
- W2997372244 hasAuthorship W2997372244A5063746171 @default.
- W2997372244 hasAuthorship W2997372244A5072170846 @default.
- W2997372244 hasAuthorship W2997372244A5076264613 @default.
- W2997372244 hasConcept C104317684 @default.
- W2997372244 hasConcept C10858879 @default.
- W2997372244 hasConcept C134018914 @default.
- W2997372244 hasConcept C139447449 @default.
- W2997372244 hasConcept C143065580 @default.
- W2997372244 hasConcept C158617107 @default.
- W2997372244 hasConcept C167625842 @default.
- W2997372244 hasConcept C185592680 @default.
- W2997372244 hasConcept C204328495 @default.
- W2997372244 hasConcept C2779306644 @default.
- W2997372244 hasConcept C55493867 @default.
- W2997372244 hasConcept C86803240 @default.
- W2997372244 hasConcept C90061646 @default.
- W2997372244 hasConcept C95444343 @default.
- W2997372244 hasConceptScore W2997372244C104317684 @default.
- W2997372244 hasConceptScore W2997372244C10858879 @default.
- W2997372244 hasConceptScore W2997372244C134018914 @default.
- W2997372244 hasConceptScore W2997372244C139447449 @default.
- W2997372244 hasConceptScore W2997372244C143065580 @default.
- W2997372244 hasConceptScore W2997372244C158617107 @default.
- W2997372244 hasConceptScore W2997372244C167625842 @default.
- W2997372244 hasConceptScore W2997372244C185592680 @default.
- W2997372244 hasConceptScore W2997372244C204328495 @default.
- W2997372244 hasConceptScore W2997372244C2779306644 @default.
- W2997372244 hasConceptScore W2997372244C55493867 @default.
- W2997372244 hasConceptScore W2997372244C86803240 @default.
- W2997372244 hasConceptScore W2997372244C90061646 @default.
- W2997372244 hasConceptScore W2997372244C95444343 @default.
- W2997372244 hasLocation W29973722441 @default.
- W2997372244 hasOpenAccess W2997372244 @default.
- W2997372244 hasPrimaryLocation W29973722441 @default.
- W2997372244 hasRelatedWork W1566239132 @default.
- W2997372244 hasRelatedWork W197914185 @default.
- W2997372244 hasRelatedWork W2014338659 @default.
- W2997372244 hasRelatedWork W2042559950 @default.
- W2997372244 hasRelatedWork W2046190285 @default.
- W2997372244 hasRelatedWork W2069247329 @default.
- W2997372244 hasRelatedWork W2076569856 @default.
- W2997372244 hasRelatedWork W2090312623 @default.
- W2997372244 hasRelatedWork W2196439712 @default.
- W2997372244 hasRelatedWork W2305253982 @default.
- W2997372244 hasRelatedWork W2326470714 @default.
- W2997372244 hasRelatedWork W2421023472 @default.
- W2997372244 hasRelatedWork W2793821186 @default.
- W2997372244 hasRelatedWork W2889562110 @default.
- W2997372244 hasRelatedWork W2958192210 @default.
- W2997372244 hasRelatedWork W2968432460 @default.
- W2997372244 hasRelatedWork W2977497658 @default.
- W2997372244 hasRelatedWork W3023198856 @default.
- W2997372244 hasRelatedWork W3030239762 @default.
- W2997372244 hasRelatedWork W3182939360 @default.
- W2997372244 isParatext "false" @default.
- W2997372244 isRetracted "false" @default.
- W2997372244 magId "2997372244" @default.
- W2997372244 workType "article" @default.