Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997374435> ?p ?o ?g. }
- W2997374435 endingPage "113876" @default.
- W2997374435 startingPage "113876" @default.
- W2997374435 abstract "The potential risks of phthalates affecting human and animal health as well as the environment are emerging as serious concerns worldwide. However, the mechanism by which phthalates induce developmental effects is under debate. Herein, we found that embryonic exposure of zebrafish to di-(2-ethylhexyl) phthalate (DEHP) and di-butyl phthalate (DBP) increased the rate of heart defects including abnormal heart rate and pericardial edema. Changes in the transcriptional profile demonstrated that genes involved in the development of the heart, such as tbx5b, nppa, ctnt, my17, cmlc1, were significantly altered by DEHP and DBP at 50 μg/L, which agreed with the abnormal cardiac outcomes. Methylated DNA immunoprecipitation sequencing (MeDIP-Seq) further showed that significant hypomethylation of nppa and ctnt was identified after DEHP and DBP exposure, which was consistent with the up-regulation of these genes. Notably, hypermethylation on the promoter region (<1 kb) of tbx5b was found after DEHP and DBP exposure, which might be responsible for its decrease in transcription. In conclusion, phthalates have the potential to induce cardiac birth defects, which might be associated with the transcriptional regulation of the involved developmental factors such as tbx5b. These findings would contribute to understand the molecular pathways that mediated the cardiac defects caused by phthalates." @default.
- W2997374435 created "2020-01-10" @default.
- W2997374435 creator A5004179735 @default.
- W2997374435 creator A5005566120 @default.
- W2997374435 creator A5011799368 @default.
- W2997374435 creator A5016047638 @default.
- W2997374435 creator A5017119483 @default.
- W2997374435 creator A5017472808 @default.
- W2997374435 creator A5023212674 @default.
- W2997374435 creator A5031306837 @default.
- W2997374435 creator A5033098921 @default.
- W2997374435 creator A5057117256 @default.
- W2997374435 creator A5062603371 @default.
- W2997374435 creator A5077389364 @default.
- W2997374435 date "2020-10-01" @default.
- W2997374435 modified "2023-10-16" @default.
- W2997374435 title "A multi-omics approach reveals molecular mechanisms by which phthalates induce cardiac defects in zebrafish (Danio rerio)" @default.
- W2997374435 cites W1612560506 @default.
- W2997374435 cites W1969494673 @default.
- W2997374435 cites W1973431915 @default.
- W2997374435 cites W1986024745 @default.
- W2997374435 cites W1988567200 @default.
- W2997374435 cites W1989376136 @default.
- W2997374435 cites W1989457690 @default.
- W2997374435 cites W1989517537 @default.
- W2997374435 cites W2004167290 @default.
- W2997374435 cites W2007217791 @default.
- W2997374435 cites W2008015562 @default.
- W2997374435 cites W2009467060 @default.
- W2997374435 cites W2012101987 @default.
- W2997374435 cites W2023549986 @default.
- W2997374435 cites W2028424692 @default.
- W2997374435 cites W2038253485 @default.
- W2997374435 cites W2039013813 @default.
- W2997374435 cites W2042645791 @default.
- W2997374435 cites W2045881191 @default.
- W2997374435 cites W2050000840 @default.
- W2997374435 cites W2059166339 @default.
- W2997374435 cites W2060519392 @default.
- W2997374435 cites W2078475439 @default.
- W2997374435 cites W2086162601 @default.
- W2997374435 cites W2087045076 @default.
- W2997374435 cites W2088008535 @default.
- W2997374435 cites W2095250399 @default.
- W2997374435 cites W2099635668 @default.
- W2997374435 cites W2102414228 @default.
- W2997374435 cites W2107295824 @default.
- W2997374435 cites W2117032037 @default.
- W2997374435 cites W2124448767 @default.
- W2997374435 cites W2134757331 @default.
- W2997374435 cites W2136703636 @default.
- W2997374435 cites W2144737161 @default.
- W2997374435 cites W2160890377 @default.
- W2997374435 cites W2165329755 @default.
- W2997374435 cites W2272124352 @default.
- W2997374435 cites W2337030717 @default.
- W2997374435 cites W2463631459 @default.
- W2997374435 cites W2572410570 @default.
- W2997374435 cites W2605312305 @default.
- W2997374435 cites W2608411225 @default.
- W2997374435 cites W2614348904 @default.
- W2997374435 cites W2622779548 @default.
- W2997374435 cites W2746997775 @default.
- W2997374435 cites W2752031753 @default.
- W2997374435 cites W2758320018 @default.
- W2997374435 cites W2769210277 @default.
- W2997374435 cites W2769528408 @default.
- W2997374435 cites W2772891021 @default.
- W2997374435 cites W2780133730 @default.
- W2997374435 cites W2793283003 @default.
- W2997374435 cites W2808711807 @default.
- W2997374435 cites W2883885571 @default.
- W2997374435 cites W2896769298 @default.
- W2997374435 cites W2901551469 @default.
- W2997374435 cites W2908062946 @default.
- W2997374435 cites W2929838469 @default.
- W2997374435 cites W2944808959 @default.
- W2997374435 cites W2949609998 @default.
- W2997374435 cites W2986398204 @default.
- W2997374435 cites W4244775966 @default.
- W2997374435 doi "https://doi.org/10.1016/j.envpol.2019.113876" @default.
- W2997374435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32806432" @default.
- W2997374435 hasPublicationYear "2020" @default.
- W2997374435 type Work @default.
- W2997374435 sameAs 2997374435 @default.
- W2997374435 citedByCount "27" @default.
- W2997374435 countsByYear W29973744352020 @default.
- W2997374435 countsByYear W29973744352021 @default.
- W2997374435 countsByYear W29973744352022 @default.
- W2997374435 countsByYear W29973744352023 @default.
- W2997374435 crossrefType "journal-article" @default.
- W2997374435 hasAuthorship W2997374435A5004179735 @default.
- W2997374435 hasAuthorship W2997374435A5005566120 @default.
- W2997374435 hasAuthorship W2997374435A5011799368 @default.
- W2997374435 hasAuthorship W2997374435A5016047638 @default.
- W2997374435 hasAuthorship W2997374435A5017119483 @default.
- W2997374435 hasAuthorship W2997374435A5017472808 @default.
- W2997374435 hasAuthorship W2997374435A5023212674 @default.