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- W2997388545 abstract "Seizure is a common complication of tuberculous meningitis (TBM), but few studies have focused on this condition. This study aimed to determine the characteristics and risk factors of adult seizure patients with TBM during long-term follow-up. Patients with TBM who were seen between June 2012 and January 2018 were retrospectively reviewed and were categorized into two groups based on the presence or absence of seizures. The seizure characteristics, outcomes and potential risk factors were assessed, with a median follow-up of 44.8 months (12.1–72.7 months). A total of 223 patients (124 male and 99 female) with TBM were enrolled, including 20.6% (46/223) with seizures. Poor outcomes, including death and disability, occurred in 56.5% (26/46) of the patients with seizures compared to 28.2% (50/177) of the patients without seizures (p < 0.001). According to the frequency of the seizures, the patients with seizures were divided into the single seizure (n = 14/46, 30.4%), repetitive seizures (n = 25/46, 54.3%), and status epilepticus (n = 7/46, 15.2%) groups. We found that non-single seizures (repetitive seizures and status epilepticus) were associated with mortality (P = 0.002, P = 0.022), while single seizure was not associated with morality (P = 0.834). In a multivariate analysis, the risk factors associated with non-single seizures were cortical involvement (p = 0.017) and epileptiform discharges (p < 0.001). Non-single seizures (repetitive seizures and status epilepticus) were associated with poor outcomes, and cortical involvement and epileptiform discharges are independent risk factors for non-single seizures." @default.
- W2997388545 created "2020-01-10" @default.
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- W2997388545 date "2019-10-01" @default.
- W2997388545 modified "2023-09-25" @default.
- W2997388545 title "Seizures in adults with tuberculous meningitis during long-term follow-up: Characteristics, outcomes and risk factors" @default.
- W2997388545 doi "https://doi.org/10.1016/j.jns.2019.10.810" @default.
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