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• W2997389989 abstract "Objective . To study the retinal nerve fibre layer (RNFL) thickness and visual electrophysiology testing in patients with Alzheimer’s disease (AD). Methods . A cross-sectional, hospital-based study: 25 AD subjects and 25 controls were recruited. Candidates who fulfil the criteria with normal ocular examinations were made to proceed with scanning laser polarimetry, pattern electroretinogram (PERG), and pattern visual evoked potential (PVEP) examinations of the right eye. RNFL thickness, PERG, and PVEP readings were evaluated. Results . In AD, the mean of average RNFL thickness was 45.28 μ m, SD = 3.61, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn></mml:mrow></mml:math> (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:mrow></mml:math>), while the superior RNFL thickness was 54.44 μ m, SD = 2.85, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn></mml:mrow></mml:math> (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:mrow></mml:math>) and inferior RNFL thickness was 47.11 μ m, SD = 4.52, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn></mml:mrow></mml:math> (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:mrow></mml:math>). For PERG, the mean P50 latency was 63.88 ms, SD = 7.94, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn></mml:mrow></mml:math> (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:mrow></mml:math>) and the mean amplitudes of P50 waves were 1.79 μ V, SD = 0.64, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M9><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn></mml:mrow></mml:math> (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M10><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:mrow></mml:math>) and N95 waves were 2.43 μ V, SD = 0.90, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M11><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn></mml:mrow></mml:math> (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M12><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:mrow></mml:math>). For PVEP, the mean latency of P100 was 119.00 ms, SD = 9.07, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M13><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn></mml:mrow></mml:math> (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M14><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:mrow></mml:math>), while the mean latency of N135 was 145.20 ms, SD = 8.53, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M15><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn></mml:mrow></mml:math> (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M16><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:mrow></mml:math>). The mean amplitude of P100 waves was 3.71 μ V, SD = 1.60, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M17><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn></mml:mrow></mml:math> (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M18><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:mrow></mml:math>), whereas the mean amplitude of N135 waves was 3.67 μ V, SD = 2.02, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M19><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn></mml:mrow></mml:math> (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M20><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:mrow></mml:math>). RNFL thickness strongly correlates with PERG readings, with P50 latency R = 0.582, R 2 = 0.339, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M21><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.002</mml:mn></mml:mrow></mml:math> (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M22><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:mrow></mml:math>), amplitude of P50 wave at R = 0.749, R 2 = 0.561, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M23><mml:mrow><mml:mi>P</mml:mi><mml:mo>≤</mml:mo><mml:mn>0.001</mml:mn></mml:mrow></mml:math> (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M24><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:mrow></mml:math>), and amplitude of N95 wave at R = 0.500, R 2 = 0.250, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M25><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.011</mml:mn></mml:mrow></mml:math> (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M26><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:mrow></mml:math>). No significant difference and correlation were observed on PVEP readings. Conclusion . The mean of the average, superior and inferior RNFL thickness were significantly lower in the AD group compared with control. There is also significant difference of PERG and PVEP parameters between AD and controls. Regression analysis showed average RNFL thickness having significantly linear relationship with the PERG parameters." @default.
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• W2997389989 date "2019-12-27" @default.
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• W2997389989 title "Evaluation of Retinal Nerve Fiber Layer Thickness, Electroretinogram and Visual Evoked Potential in Patients with Alzheimer’s Disease" @default.
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