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- W2997391651 endingPage "261" @default.
- W2997391651 startingPage "261" @default.
- W2997391651 abstract "The tumor suppressor p53 and its homologues, p63 and p73, play a pivotal role in the regulation of the DNA damage response, cellular homeostasis, development, aging, and metabolism. A number of mouse studies have shown that a genetic defect in the p53 family could lead to spontaneous tumor development, embryonic lethality, or severe tissue abnormality, indicating that the activity of the p53 family must be tightly regulated to maintain normal cellular functions. While the p53 family members are regulated at the level of gene expression as well as post-translational modification, they are also controlled at the level of protein stability through the ubiquitin proteasomal pathway. Over the last 20 years, many ubiquitin E3 ligases have been discovered that directly promote protein degradation of p53, p63, and p73 in vitro and in vivo. Here, we provide an overview of such E3 ligases and discuss their roles and functions." @default.
- W2997391651 created "2020-01-10" @default.
- W2997391651 creator A5010298708 @default.
- W2997391651 creator A5012538768 @default.
- W2997391651 creator A5078110565 @default.
- W2997391651 date "2019-12-30" @default.
- W2997391651 modified "2023-10-16" @default.
- W2997391651 title "Regulation of the p53 Family Proteins by the Ubiquitin Proteasomal Pathway" @default.
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