Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997394078> ?p ?o ?g. }
- W2997394078 endingPage "176" @default.
- W2997394078 startingPage "176" @default.
- W2997394078 abstract "Lipid metabolism dysfunction and obesity are serious health issues to human beings. The current study investigated the effects of hyperbaric oxygen (HBO) against high fat diet (HFD)-induced lipid metabolism dysfunction and the roles of L-carnitine. C57/B6 mice were fed with HFD or normal chew diet, with or without HBO treatment. Histopathological methods were used to assess the adipose tissues, serum free fatty acid (FFA) levels were assessed with enzymatic methods, and the endogenous circulation and skeletal muscle L-carnitine levels were assessed with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Additionally, western blotting was used to assess the expression levels of PPARα, CPT1b, pHSL/HSL, and UCP1. HFD treatment increased body/adipose tissue weight, serum FFA levels, circulation L-carnitines and decreased skeletal muscle L-carnitine levels, while HBO treatment alleviated such changes. Moreover, HFD treatment increased fatty acid deposition in adipose tissues and decreased the expression of HSL, while HBO treatment alleviated such changes. Additionally, HFD treatment decreased the expression levels of PPARα and increased those of CPT1b in skeletal muscle, while HBO treatment effectively reverted such changes as well. In brown adipose tissues, HFD increased the expression of UCP1 and the phosphorylation of HSL, which was abolished by HBO treatment as well. In summary, HBO treatment may alleviate HFD-induced fatty acid metabolism dysfunction in C57/B6 mice, which seems to be associated with circulation and skeletal muscle L-carnitine levels and PPARα expression." @default.
- W2997394078 created "2020-01-10" @default.
- W2997394078 creator A5007055012 @default.
- W2997394078 creator A5008078220 @default.
- W2997394078 creator A5014648221 @default.
- W2997394078 creator A5029941351 @default.
- W2997394078 creator A5030335306 @default.
- W2997394078 creator A5044257848 @default.
- W2997394078 creator A5046214153 @default.
- W2997394078 creator A5052819410 @default.
- W2997394078 creator A5053886220 @default.
- W2997394078 creator A5063225106 @default.
- W2997394078 creator A5089382995 @default.
- W2997394078 creator A5090425659 @default.
- W2997394078 date "2020-01-01" @default.
- W2997394078 modified "2023-10-14" @default.
- W2997394078 title "L-Carnitine Is Involved in Hyperbaric Oxygen-Mediated Therapeutic Effects in High Fat Diet-Induced Lipid Metabolism Dysfunction" @default.
- W2997394078 cites W1499428090 @default.
- W2997394078 cites W1930444548 @default.
- W2997394078 cites W1966829821 @default.
- W2997394078 cites W1968383118 @default.
- W2997394078 cites W1971849125 @default.
- W2997394078 cites W1983457010 @default.
- W2997394078 cites W1988521921 @default.
- W2997394078 cites W1996530980 @default.
- W2997394078 cites W2002094413 @default.
- W2997394078 cites W2020690251 @default.
- W2997394078 cites W2038987131 @default.
- W2997394078 cites W2045175945 @default.
- W2997394078 cites W2055204766 @default.
- W2997394078 cites W2058363104 @default.
- W2997394078 cites W2076432521 @default.
- W2997394078 cites W2076470803 @default.
- W2997394078 cites W2088262190 @default.
- W2997394078 cites W2101096393 @default.
- W2997394078 cites W2106111056 @default.
- W2997394078 cites W2107283085 @default.
- W2997394078 cites W2111028161 @default.
- W2997394078 cites W2130025116 @default.
- W2997394078 cites W2132570401 @default.
- W2997394078 cites W2144741116 @default.
- W2997394078 cites W2145842201 @default.
- W2997394078 cites W2149434047 @default.
- W2997394078 cites W2153616177 @default.
- W2997394078 cites W2177994059 @default.
- W2997394078 cites W2337846008 @default.
- W2997394078 cites W2404155588 @default.
- W2997394078 cites W2407296174 @default.
- W2997394078 cites W2473672715 @default.
- W2997394078 cites W2607648378 @default.
- W2997394078 cites W2750109605 @default.
- W2997394078 cites W2755408736 @default.
- W2997394078 cites W2758057470 @default.
- W2997394078 cites W2763465533 @default.
- W2997394078 cites W2774310545 @default.
- W2997394078 cites W2782608603 @default.
- W2997394078 cites W2789926851 @default.
- W2997394078 cites W2793285997 @default.
- W2997394078 cites W2804738513 @default.
- W2997394078 cites W2810347522 @default.
- W2997394078 cites W2891997623 @default.
- W2997394078 cites W2903331848 @default.
- W2997394078 cites W2918766683 @default.
- W2997394078 cites W2922925343 @default.
- W2997394078 cites W2924113793 @default.
- W2997394078 cites W2935594086 @default.
- W2997394078 cites W2938533536 @default.
- W2997394078 cites W2944797064 @default.
- W2997394078 cites W2951372275 @default.
- W2997394078 cites W2954913534 @default.
- W2997394078 cites W2969954155 @default.
- W2997394078 cites W2971793826 @default.
- W2997394078 cites W2977727431 @default.
- W2997394078 cites W2982601120 @default.
- W2997394078 cites W4302435679 @default.
- W2997394078 doi "https://doi.org/10.3390/molecules25010176" @default.
- W2997394078 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6982999" @default.
- W2997394078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31906305" @default.
- W2997394078 hasPublicationYear "2020" @default.
- W2997394078 type Work @default.
- W2997394078 sameAs 2997394078 @default.
- W2997394078 citedByCount "7" @default.
- W2997394078 countsByYear W29973940782020 @default.
- W2997394078 countsByYear W29973940782022 @default.
- W2997394078 countsByYear W29973940782023 @default.
- W2997394078 crossrefType "journal-article" @default.
- W2997394078 hasAuthorship W2997394078A5007055012 @default.
- W2997394078 hasAuthorship W2997394078A5008078220 @default.
- W2997394078 hasAuthorship W2997394078A5014648221 @default.
- W2997394078 hasAuthorship W2997394078A5029941351 @default.
- W2997394078 hasAuthorship W2997394078A5030335306 @default.
- W2997394078 hasAuthorship W2997394078A5044257848 @default.
- W2997394078 hasAuthorship W2997394078A5046214153 @default.
- W2997394078 hasAuthorship W2997394078A5052819410 @default.
- W2997394078 hasAuthorship W2997394078A5053886220 @default.
- W2997394078 hasAuthorship W2997394078A5063225106 @default.
- W2997394078 hasAuthorship W2997394078A5089382995 @default.
- W2997394078 hasAuthorship W2997394078A5090425659 @default.