Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997415907> ?p ?o ?g. }
- W2997415907 endingPage "63" @default.
- W2997415907 startingPage "63" @default.
- W2997415907 abstract "While alkaloids often exert unique pharmacological effects on animal cells, exposure of sea urchin eggs to nicotine causes polyspermy at fertilization in a dose-dependent manner. Here, we studied molecular mechanisms underlying the phenomenon. Although nicotine is an agonist of ionotropic acetylcholine receptors, we found that nicotine-induced polyspermy was neither mimicked by acetylcholine and carbachol nor inhibited by specific antagonists of nicotinic acetylcholine receptors. Unlike acetylcholine and carbachol, nicotine uniquely induced drastic rearrangement of egg cortical microfilaments in a dose-dependent way. Such cytoskeletal changes appeared to render the eggs more receptive to sperm, as judged by the significant alleviation of polyspermy by latrunculin-A and mycalolide-B. In addition, our fluorimetric assay provided the first evidence that nicotine directly accelerates polymerization kinetics of G-actin and attenuates depolymerization of preassembled F-actin. Furthermore, nicotine inhibited cofilin-induced disassembly of F-actin. Unexpectedly, our results suggest that effects of nicotine can also be mediated in some non-cholinergic pathways." @default.
- W2997415907 created "2020-01-10" @default.
- W2997415907 creator A5011524285 @default.
- W2997415907 creator A5040888047 @default.
- W2997415907 creator A5053863403 @default.
- W2997415907 creator A5065203978 @default.
- W2997415907 date "2019-12-25" @default.
- W2997415907 modified "2023-10-17" @default.
- W2997415907 title "Nicotine Induces Polyspermy in Sea Urchin Eggs through a Non-Cholinergic Pathway Modulating Actin Dynamics" @default.
- W2997415907 cites W1488840584 @default.
- W2997415907 cites W1530462575 @default.
- W2997415907 cites W1594018550 @default.
- W2997415907 cites W1963897156 @default.
- W2997415907 cites W1967546275 @default.
- W2997415907 cites W1970844302 @default.
- W2997415907 cites W1971949189 @default.
- W2997415907 cites W1972516189 @default.
- W2997415907 cites W1973678364 @default.
- W2997415907 cites W1974123836 @default.
- W2997415907 cites W1979607880 @default.
- W2997415907 cites W1982189746 @default.
- W2997415907 cites W1983578658 @default.
- W2997415907 cites W1983667127 @default.
- W2997415907 cites W1985493073 @default.
- W2997415907 cites W1992109950 @default.
- W2997415907 cites W1998134411 @default.
- W2997415907 cites W1999633797 @default.
- W2997415907 cites W2003823135 @default.
- W2997415907 cites W2013217130 @default.
- W2997415907 cites W2013815934 @default.
- W2997415907 cites W2014393697 @default.
- W2997415907 cites W2014720456 @default.
- W2997415907 cites W2016502506 @default.
- W2997415907 cites W2029466947 @default.
- W2997415907 cites W2037735194 @default.
- W2997415907 cites W2042138391 @default.
- W2997415907 cites W2042228635 @default.
- W2997415907 cites W2044089941 @default.
- W2997415907 cites W2049672050 @default.
- W2997415907 cites W2055224266 @default.
- W2997415907 cites W2057781252 @default.
- W2997415907 cites W2062162510 @default.
- W2997415907 cites W2062233864 @default.
- W2997415907 cites W2065808106 @default.
- W2997415907 cites W2065883986 @default.
- W2997415907 cites W2068971123 @default.
- W2997415907 cites W2079583526 @default.
- W2997415907 cites W2081717340 @default.
- W2997415907 cites W2081751593 @default.
- W2997415907 cites W2085190322 @default.
- W2997415907 cites W2091039099 @default.
- W2997415907 cites W2094116868 @default.
- W2997415907 cites W2095256261 @default.
- W2997415907 cites W2104838343 @default.
- W2997415907 cites W2110315172 @default.
- W2997415907 cites W2115460562 @default.
- W2997415907 cites W2116876132 @default.
- W2997415907 cites W2133229697 @default.
- W2997415907 cites W2133586479 @default.
- W2997415907 cites W2139755540 @default.
- W2997415907 cites W2147218540 @default.
- W2997415907 cites W2148016606 @default.
- W2997415907 cites W2168339066 @default.
- W2997415907 cites W2169440970 @default.
- W2997415907 cites W2174736803 @default.
- W2997415907 cites W2174802300 @default.
- W2997415907 cites W2320814947 @default.
- W2997415907 cites W2343294831 @default.
- W2997415907 cites W2345001147 @default.
- W2997415907 cites W2468762626 @default.
- W2997415907 cites W2742893576 @default.
- W2997415907 cites W2744033075 @default.
- W2997415907 cites W2786796969 @default.
- W2997415907 cites W2797525472 @default.
- W2997415907 cites W2885807357 @default.
- W2997415907 cites W2885988216 @default.
- W2997415907 cites W2887001450 @default.
- W2997415907 cites W2895692023 @default.
- W2997415907 cites W2911670766 @default.
- W2997415907 cites W291654744 @default.
- W2997415907 cites W2944535696 @default.
- W2997415907 cites W2967151684 @default.
- W2997415907 cites W2968967661 @default.
- W2997415907 cites W4297917728 @default.
- W2997415907 cites W1981857435 @default.
- W2997415907 doi "https://doi.org/10.3390/cells9010063" @default.
- W2997415907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7016604" @default.
- W2997415907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31881774" @default.
- W2997415907 hasPublicationYear "2019" @default.
- W2997415907 type Work @default.
- W2997415907 sameAs 2997415907 @default.
- W2997415907 citedByCount "7" @default.
- W2997415907 countsByYear W29974159072020 @default.
- W2997415907 countsByYear W29974159072021 @default.
- W2997415907 countsByYear W29974159072022 @default.
- W2997415907 countsByYear W29974159072023 @default.
- W2997415907 crossrefType "journal-article" @default.
- W2997415907 hasAuthorship W2997415907A5011524285 @default.