FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997443409> ?p ?o ?g. }

• W2997443409 abstract "Abstract Background Egg-induced immune response and granuloma formation are thought to be the basis of central nervous system (CNS)-related clinical symptoms of Schistosoma japonicum . Microglia/macrophages are the major immune cells involved in detection and subsequent elimination of pathogens and injured tissue in the brain. However, little is known about their role in the pathogenesis of neuroschistosomiasis. The main purpose of the study is to clarify the pathological involvement of microglia/macrophages in the pathogenesis of neuroschistosomiasis (NS). Methods Staining techniques were applied to the granuloma tissues excised from 4 patients, as well as mice model which was established by microinjecting viable S. japonicum eggs into the brain. Clinical features of the patients and neurological symptoms in mice were also collected and analyzed in terms of their correlation with microglia/macrophages. Results Microglia/macrophages constituted the major portions of the granulomas surrounding the eggs in both all human cases and S. japonicum egg-injected mice. Granuloma persisted in all patients accompanied by unremitted neurological symptoms, while in mice granuloma formation initiated on day 3, peaked on day 7 and subsided on day 30 post injection with S. japonicum eggs. No neurological abnormalities were observed in egg-injected mice except for significant weight decrease on day 3 compared with saline-injected control. M1 polarization of microglia/macrophages was confirmed in egg-injected mice 3 days post injection and in all human cases. M2 polarization was absent in human patients despite the duration of complaints but dominated in the whole progression of egg-induced pathology in mice until the elimination of eggs and subsidence of neuroinflammation on day 30 post injection. Conclusions Microglia/macrophages participated actively in the granuloma microenvironment of encephalic schistosomiasis japonicum in both human and mice. The polarization pattern of microglia/macrophages coincided with the symptomatic features in human cases and S. japonicum egg-injected mice, indicating M2 instead of M1 activation as a probably more important mediator in the battle against egg-induced pathology and concomitant manifestations. These new findings will shed light on the pathogenesis of NS from a brand-new perspective, and may contribute to the immunotherapy development for such disease, favoring perhaps M2 polarization of microglia/macrophages as a feasible strategy." @default.
• W2997443409 created "2020-01-10" @default.
• W2997443409 creator A5014818059 @default.
• W2997443409 creator A5039269596 @default.
• W2997443409 creator A5045366030 @default.
• W2997443409 creator A5058670321 @default.
• W2997443409 creator A5069596466 @default.
• W2997443409 creator A5085346915 @default.
• W2997443409 creator A5088973373 @default.
• W2997443409 date "2019-12-01" @default.
• W2997443409 modified "2023-10-07" @default.
• W2997443409 title "Identification and characterization of microglia/macrophages in the granuloma microenvironment of encephalic schistosomiasis japonicum" @default.
• W2997443409 cites W1817666133 @default.
• W2997443409 cites W1967832961 @default.
• W2997443409 cites W1976266513 @default.
• W2997443409 cites W1977213877 @default.
• W2997443409 cites W2006517495 @default.
• W2997443409 cites W2024981949 @default.
• W2997443409 cites W2026799520 @default.
• W2997443409 cites W2041551162 @default.
• W2997443409 cites W2053176712 @default.
• W2997443409 cites W2054311525 @default.
• W2997443409 cites W2054472394 @default.
• W2997443409 cites W2054552572 @default.
• W2997443409 cites W2058669152 @default.
• W2997443409 cites W2061123122 @default.
• W2997443409 cites W2067267561 @default.
• W2997443409 cites W2074902461 @default.
• W2997443409 cites W2086531222 @default.
• W2997443409 cites W2095334969 @default.
• W2997443409 cites W2096182847 @default.
• W2997443409 cites W2104901632 @default.
• W2997443409 cites W2106105150 @default.
• W2997443409 cites W2110469147 @default.
• W2997443409 cites W2123442007 @default.
• W2997443409 cites W2134729461 @default.
• W2997443409 cites W2164829753 @default.
• W2997443409 cites W2170899083 @default.
• W2997443409 cites W2209119157 @default.
• W2997443409 cites W2336534940 @default.
• W2997443409 cites W2552476469 @default.
• W2997443409 cites W2566055752 @default.
• W2997443409 cites W2605987957 @default.
• W2997443409 cites W2704780929 @default.
• W2997443409 cites W2753418543 @default.
• W2997443409 cites W2767585546 @default.
• W2997443409 cites W2781961392 @default.
• W2997443409 cites W2901813974 @default.
• W2997443409 cites W2905139641 @default.
• W2997443409 cites W4211093028 @default.
• W2997443409 cites W4211236620 @default.
• W2997443409 cites W4250815034 @default.
• W2997443409 cites W53286860 @default.
• W2997443409 doi "https://doi.org/10.1186/s12879-019-4725-5" @default.
• W2997443409 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6937796" @default.
• W2997443409 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31888505" @default.
• W2997443409 hasPublicationYear "2019" @default.
• W2997443409 type Work @default.
• W2997443409 sameAs 2997443409 @default.
• W2997443409 citedByCount "8" @default.
• W2997443409 countsByYear W29974434092020 @default.
• W2997443409 countsByYear W29974434092021 @default.
• W2997443409 countsByYear W29974434092022 @default.
• W2997443409 countsByYear W29974434092023 @default.
• W2997443409 crossrefType "journal-article" @default.
• W2997443409 hasAuthorship W2997443409A5014818059 @default.
• W2997443409 hasAuthorship W2997443409A5039269596 @default.
• W2997443409 hasAuthorship W2997443409A5045366030 @default.
• W2997443409 hasAuthorship W2997443409A5058670321 @default.
• W2997443409 hasAuthorship W2997443409A5069596466 @default.
• W2997443409 hasAuthorship W2997443409A5085346915 @default.
• W2997443409 hasAuthorship W2997443409A5088973373 @default.
• W2997443409 hasBestOaLocation W29974434091 @default.
• W2997443409 hasConcept C134018914 @default.
• W2997443409 hasConcept C142724271 @default.
• W2997443409 hasConcept C165901193 @default.
• W2997443409 hasConcept C203014093 @default.
• W2997443409 hasConcept C207886595 @default.
• W2997443409 hasConcept C2776225656 @default.
• W2997443409 hasConcept C2776863245 @default.
• W2997443409 hasConcept C2776914184 @default.
• W2997443409 hasConcept C2777123769 @default.
• W2997443409 hasConcept C2778491710 @default.
• W2997443409 hasConcept C2779830541 @default.
• W2997443409 hasConcept C2780140890 @default.
• W2997443409 hasConcept C2780942790 @default.
• W2997443409 hasConcept C529278444 @default.
• W2997443409 hasConcept C71924100 @default.
• W2997443409 hasConcept C86803240 @default.
• W2997443409 hasConcept C8891405 @default.
• W2997443409 hasConceptScore W2997443409C134018914 @default.
• W2997443409 hasConceptScore W2997443409C142724271 @default.
• W2997443409 hasConceptScore W2997443409C165901193 @default.
• W2997443409 hasConceptScore W2997443409C203014093 @default.
• W2997443409 hasConceptScore W2997443409C207886595 @default.
• W2997443409 hasConceptScore W2997443409C2776225656 @default.
• W2997443409 hasConceptScore W2997443409C2776863245 @default.
• W2997443409 hasConceptScore W2997443409C2776914184 @default.
• W2997443409 hasConceptScore W2997443409C2777123769 @default.
• W2997443409 hasConceptScore W2997443409C2778491710 @default.

• next