Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997452015> ?p ?o ?g. }
- W2997452015 endingPage "31" @default.
- W2997452015 startingPage "19" @default.
- W2997452015 abstract "Abstract Lipid oxidation results in the formation of many reactive products, such as small aldehydes, substituted alkenals, and cyclopentenone prostaglandins, which are all able to form covalent adducts with nucleophilic residues of proteins. This process is called lipoxidation, and the resulting adducts are called advanced lipoxidation end products (ALEs), by analogy with the formation of advanced glycoxidation end products from oxidized sugars. Modification of proteins by reactive oxidized lipids leads to structural changes such as increased β-sheet conformation, which tends to result in amyloid-like structures and oligomerization, or unfolding and aggregation. Reaction with catalytic cysteines is often responsible for the loss of enzymatic activity in lipoxidized proteins, although inhibition may also occur through conformational changes at more distant sites affecting substrate binding or regulation. On the other hand, a few proteins are activated by lipoxidation-induced oligomerization or interactions, leading to increased downstream signalling. At the cellular level, it is clear that some proteins are much more susceptible to lipoxidation than others. ALEs affect cell metabolism, protein–protein interactions, protein turnover via the proteasome, and cell viability. Evidence is building that they play roles in both physiological and pathological situations, and inhibiting ALE formation can have beneficial effects." @default.
- W2997452015 created "2020-01-10" @default.
- W2997452015 creator A5035356657 @default.
- W2997452015 creator A5081930302 @default.
- W2997452015 date "2019-12-23" @default.
- W2997452015 modified "2023-09-27" @default.
- W2997452015 title "Modification of proteins by reactive lipid oxidation products and biochemical effects of lipoxidation" @default.
- W2997452015 cites W1028927773 @default.
- W2997452015 cites W1502736133 @default.
- W2997452015 cites W1757834753 @default.
- W2997452015 cites W1845308957 @default.
- W2997452015 cites W1967103312 @default.
- W2997452015 cites W1973393664 @default.
- W2997452015 cites W1976382640 @default.
- W2997452015 cites W1978104803 @default.
- W2997452015 cites W1985775184 @default.
- W2997452015 cites W1996914535 @default.
- W2997452015 cites W2001296325 @default.
- W2997452015 cites W2003515503 @default.
- W2997452015 cites W2014653612 @default.
- W2997452015 cites W2015588180 @default.
- W2997452015 cites W2022433801 @default.
- W2997452015 cites W2022866015 @default.
- W2997452015 cites W2027575720 @default.
- W2997452015 cites W2029032182 @default.
- W2997452015 cites W2034713072 @default.
- W2997452015 cites W2035676834 @default.
- W2997452015 cites W2036591638 @default.
- W2997452015 cites W2041129829 @default.
- W2997452015 cites W2044357091 @default.
- W2997452015 cites W2045843284 @default.
- W2997452015 cites W2053769775 @default.
- W2997452015 cites W2055512409 @default.
- W2997452015 cites W2056258976 @default.
- W2997452015 cites W2061676392 @default.
- W2997452015 cites W2068980704 @default.
- W2997452015 cites W2074706442 @default.
- W2997452015 cites W2077753473 @default.
- W2997452015 cites W2095190072 @default.
- W2997452015 cites W2107516773 @default.
- W2997452015 cites W2110966376 @default.
- W2997452015 cites W2112130248 @default.
- W2997452015 cites W2124263476 @default.
- W2997452015 cites W2126593560 @default.
- W2997452015 cites W2131050015 @default.
- W2997452015 cites W2136497849 @default.
- W2997452015 cites W2143167988 @default.
- W2997452015 cites W2153400793 @default.
- W2997452015 cites W2164094004 @default.
- W2997452015 cites W2175496478 @default.
- W2997452015 cites W2202386927 @default.
- W2997452015 cites W2207411223 @default.
- W2997452015 cites W2295813732 @default.
- W2997452015 cites W2318905955 @default.
- W2997452015 cites W2330995972 @default.
- W2997452015 cites W2332724176 @default.
- W2997452015 cites W2338110831 @default.
- W2997452015 cites W2413916305 @default.
- W2997452015 cites W2468517437 @default.
- W2997452015 cites W2547550880 @default.
- W2997452015 cites W2569997475 @default.
- W2997452015 cites W2586966505 @default.
- W2997452015 cites W2613503316 @default.
- W2997452015 cites W273164267 @default.
- W2997452015 cites W2747992634 @default.
- W2997452015 cites W2749337106 @default.
- W2997452015 cites W2765692827 @default.
- W2997452015 cites W2767678580 @default.
- W2997452015 cites W2771359783 @default.
- W2997452015 cites W2789331928 @default.
- W2997452015 cites W2790704022 @default.
- W2997452015 cites W2793298604 @default.
- W2997452015 cites W2795868113 @default.
- W2997452015 cites W2796231550 @default.
- W2997452015 cites W2807975858 @default.
- W2997452015 cites W2889368382 @default.
- W2997452015 cites W2890125882 @default.
- W2997452015 cites W2903733428 @default.
- W2997452015 cites W2904409366 @default.
- W2997452015 cites W2905091255 @default.
- W2997452015 cites W2906929202 @default.
- W2997452015 cites W2907189080 @default.
- W2997452015 cites W2910399023 @default.
- W2997452015 cites W2910606659 @default.
- W2997452015 cites W2911005360 @default.
- W2997452015 cites W2913216235 @default.
- W2997452015 cites W2921929778 @default.
- W2997452015 cites W2924752837 @default.
- W2997452015 cites W2939666757 @default.
- W2997452015 cites W2948051078 @default.
- W2997452015 cites W2951338623 @default.
- W2997452015 cites W2969174611 @default.
- W2997452015 cites W2981499126 @default.
- W2997452015 doi "https://doi.org/10.1042/ebc20190058" @default.
- W2997452015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31867621" @default.
- W2997452015 hasPublicationYear "2019" @default.
- W2997452015 type Work @default.
- W2997452015 sameAs 2997452015 @default.