FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997453099> ?p ?o ?g. }

• W2997453099 endingPage "1654" @default.
• W2997453099 startingPage "1643" @default.
• W2997453099 abstract "The physiological roles of thyrotropin-releasing hormone (TRH) are proposed to be mediated by TRH receptors (TRHR), which have been divided into 3 subtypes, namely, TRHR1, TRHR2, and TRHR3, in vertebrates. Although 2 TRH receptors (TRHR1 and TRHR3) have been predicted to exist in birds, it remains unclear whether TRHR3 is a functional TRH receptor similar to TRHR1. Here, we reported the functionality and tissue expression of TRHR3 in chickens. The cloned chicken TRHR3 (cTRHR3) encodes a receptor of 387 amino acids, which shares high-amino-acid identities (63-80%) to TRHR3 of parrots, lizards, Xenopus tropicalis, and tilapia and comparatively lower sequence identities to chicken TRHR1 or mouse TRHR2. Using cell-based luciferase reporter assays and Western blot, we demonstrated that similar to chicken TRHR1 (cTRHR1), cTRHR3 expressed in HEK 293 cells can be potently activated by TRH and that its activation stimulates multiple signaling pathways, indicating both TRH receptors are functional. Quantitative real-time PCR revealed that cTRHR1 and cTRHR3 are widely, but differentially, expressed in chicken tissues, and their expression is likely controlled by promoters located upstream of exon 1, which display strong promoter activities in cultured DF-1 cells. cTRHR1 is highly expressed in the anterior pituitary and testes, while cTRHR3 is highly expressed in the muscle, testes, fat, pituitary, spinal cord, and many brain regions (including hypothalamus). These findings indicate that TRH actions are likely mediated by 2 TRH receptors in chickens. In conclusion, our data provide the first piece of evidence that both cTRHR3 and cTRHR1 are functional TRH receptors, which helps to elucidate the physiological roles of TRH in birds." @default.
• W2997453099 created "2020-01-10" @default.
• W2997453099 creator A5015307943 @default.
• W2997453099 creator A5067100305 @default.
• W2997453099 creator A5072852596 @default.
• W2997453099 creator A5087171601 @default.
• W2997453099 creator A5087736842 @default.
• W2997453099 creator A5088533080 @default.
• W2997453099 date "2020-03-01" @default.
• W2997453099 modified "2023-10-18" @default.
• W2997453099 title "Characterization of a novel thyrotropin-releasing hormone receptor, TRHR3, in chickens" @default.
• W2997453099 cites W1520784224 @default.
• W2997453099 cites W1594381616 @default.
• W2997453099 cites W1671010149 @default.
• W2997453099 cites W1787873480 @default.
• W2997453099 cites W1821817384 @default.
• W2997453099 cites W1968883430 @default.
• W2997453099 cites W1968930722 @default.
• W2997453099 cites W1971179516 @default.
• W2997453099 cites W1982637424 @default.
• W2997453099 cites W1989491900 @default.
• W2997453099 cites W2003317484 @default.
• W2997453099 cites W2003462078 @default.
• W2997453099 cites W2004077337 @default.
• W2997453099 cites W2016846694 @default.
• W2997453099 cites W2020645580 @default.
• W2997453099 cites W2021678580 @default.
• W2997453099 cites W2022797453 @default.
• W2997453099 cites W2035103640 @default.
• W2997453099 cites W2039412078 @default.
• W2997453099 cites W2042189473 @default.
• W2997453099 cites W2048933641 @default.
• W2997453099 cites W2053620197 @default.
• W2997453099 cites W2064955150 @default.
• W2997453099 cites W2065097245 @default.
• W2997453099 cites W2069089926 @default.
• W2997453099 cites W2072756819 @default.
• W2997453099 cites W2075947323 @default.
• W2997453099 cites W2080899899 @default.
• W2997453099 cites W2083118347 @default.
• W2997453099 cites W2085189270 @default.
• W2997453099 cites W2087547931 @default.
• W2997453099 cites W2093756666 @default.
• W2997453099 cites W2094213744 @default.
• W2997453099 cites W2095130078 @default.
• W2997453099 cites W2103086587 @default.
• W2997453099 cites W2114793335 @default.
• W2997453099 cites W2120067804 @default.
• W2997453099 cites W2129991236 @default.
• W2997453099 cites W2130799585 @default.
• W2997453099 cites W2132898409 @default.
• W2997453099 cites W2140972028 @default.
• W2997453099 cites W2146554841 @default.
• W2997453099 cites W2154893310 @default.
• W2997453099 cites W2168866083 @default.
• W2997453099 cites W2267040991 @default.
• W2997453099 cites W2342677200 @default.
• W2997453099 cites W2614062200 @default.
• W2997453099 cites W2805813923 @default.
• W2997453099 cites W384619564 @default.
• W2997453099 cites W4237081648 @default.
• W2997453099 cites W4292239814 @default.
• W2997453099 doi "https://doi.org/10.1016/j.psj.2019.10.062" @default.
• W2997453099 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7587745" @default.
• W2997453099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32115036" @default.
• W2997453099 hasPublicationYear "2020" @default.
• W2997453099 type Work @default.
• W2997453099 sameAs 2997453099 @default.
• W2997453099 citedByCount "5" @default.
• W2997453099 countsByYear W29974530992021 @default.
• W2997453099 countsByYear W29974530992022 @default.
• W2997453099 crossrefType "journal-article" @default.
• W2997453099 hasAuthorship W2997453099A5015307943 @default.
• W2997453099 hasAuthorship W2997453099A5067100305 @default.
• W2997453099 hasAuthorship W2997453099A5072852596 @default.
• W2997453099 hasAuthorship W2997453099A5087171601 @default.
• W2997453099 hasAuthorship W2997453099A5087736842 @default.
• W2997453099 hasAuthorship W2997453099A5088533080 @default.
• W2997453099 hasBestOaLocation W29974530991 @default.
• W2997453099 hasConcept C104317684 @default.
• W2997453099 hasConcept C126322002 @default.
• W2997453099 hasConcept C134018914 @default.
• W2997453099 hasConcept C153911025 @default.
• W2997453099 hasConcept C170493617 @default.
• W2997453099 hasConcept C174510640 @default.
• W2997453099 hasConcept C2776216936 @default.
• W2997453099 hasConcept C2776415932 @default.
• W2997453099 hasConcept C2779535977 @default.
• W2997453099 hasConcept C515207424 @default.
• W2997453099 hasConcept C55493867 @default.
• W2997453099 hasConcept C71315377 @default.
• W2997453099 hasConcept C71924100 @default.
• W2997453099 hasConcept C86803240 @default.
• W2997453099 hasConceptScore W2997453099C104317684 @default.
• W2997453099 hasConceptScore W2997453099C126322002 @default.
• W2997453099 hasConceptScore W2997453099C134018914 @default.
• W2997453099 hasConceptScore W2997453099C153911025 @default.
• W2997453099 hasConceptScore W2997453099C170493617 @default.

• next