FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997464722> ?p ?o ?g. }

• W2997464722 endingPage "103551" @default.
• W2997464722 startingPage "103551" @default.
• W2997464722 abstract "Six new guaiane-type sesquiterpenes (1–6), and one monoterpenoid (7) along with five known analogues (8–12), were isolated from the leaves of Artemisia argyi Lévl et Vant. The new compounds were characterized by the basic analysis of the spectroscopic data (HRMS, 1D and 2D NMR), and the absolute configurations were determined by both calculated electronic circular dichroism and DP4 calculations. The inhibitory effects of 1–12 against human gastric adenocarcinoma (AGS) cells were investigated in vitro, among which 1–3 and 8 showed remarkable cytotoxic activity with IC50 values in the range of 6.69–10.25 μM. The results suggested that the variation in the inhibitory activities of the compounds are the result of different substitutions on C-8. In order to rationalize the binding interactions of active compounds with the active site of NF-кB, in silico study was conducted and the results were in complete agreement with the experimental data for cytotoxicity evaluation." @default.
• W2997464722 created "2020-01-10" @default.
• W2997464722 creator A5004612489 @default.
• W2997464722 creator A5009695592 @default.
• W2997464722 creator A5025127938 @default.
• W2997464722 creator A5034938461 @default.
• W2997464722 creator A5080233751 @default.
• W2997464722 date "2020-01-01" @default.
• W2997464722 modified "2023-10-18" @default.
• W2997464722 title "Polyhydroxyl guaianolide terpenoids as potential NF-кB inhibitors induced cytotoxicity in human gastric adenocarcinoma cell line" @default.
• W2997464722 cites W1971985703 @default.
• W2997464722 cites W1974627037 @default.
• W2997464722 cites W1977661571 @default.
• W2997464722 cites W1999662352 @default.
• W2997464722 cites W2000252737 @default.
• W2997464722 cites W2002850470 @default.
• W2997464722 cites W2013188102 @default.
• W2997464722 cites W2014367025 @default.
• W2997464722 cites W2036824368 @default.
• W2997464722 cites W2038752135 @default.
• W2997464722 cites W2040895935 @default.
• W2997464722 cites W2043892945 @default.
• W2997464722 cites W2058151515 @default.
• W2997464722 cites W2060674413 @default.
• W2997464722 cites W2068118439 @default.
• W2997464722 cites W2072413417 @default.
• W2997464722 cites W2135187058 @default.
• W2997464722 cites W2199516363 @default.
• W2997464722 cites W2415398384 @default.
• W2997464722 cites W2546833535 @default.
• W2997464722 cites W2585354656 @default.
• W2997464722 cites W2779605628 @default.
• W2997464722 cites W2948535991 @default.
• W2997464722 cites W2952774264 @default.
• W2997464722 cites W4211161027 @default.
• W2997464722 doi "https://doi.org/10.1016/j.bioorg.2019.103551" @default.
• W2997464722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31911301" @default.
• W2997464722 hasPublicationYear "2020" @default.
• W2997464722 type Work @default.
• W2997464722 sameAs 2997464722 @default.
• W2997464722 citedByCount "7" @default.
• W2997464722 countsByYear W29974647222021 @default.
• W2997464722 countsByYear W29974647222022 @default.
• W2997464722 countsByYear W29974647222023 @default.
• W2997464722 crossrefType "journal-article" @default.
• W2997464722 hasAuthorship W2997464722A5004612489 @default.
• W2997464722 hasAuthorship W2997464722A5009695592 @default.
• W2997464722 hasAuthorship W2997464722A5025127938 @default.
• W2997464722 hasAuthorship W2997464722A5034938461 @default.
• W2997464722 hasAuthorship W2997464722A5080233751 @default.
• W2997464722 hasConcept C104317684 @default.
• W2997464722 hasConcept C109316439 @default.
• W2997464722 hasConcept C121608353 @default.
• W2997464722 hasConcept C126322002 @default.
• W2997464722 hasConcept C133571119 @default.
• W2997464722 hasConcept C169760540 @default.
• W2997464722 hasConcept C17077164 @default.
• W2997464722 hasConcept C185592680 @default.
• W2997464722 hasConcept C19549132 @default.
• W2997464722 hasConcept C202751555 @default.
• W2997464722 hasConcept C206103511 @default.
• W2997464722 hasConcept C25170562 @default.
• W2997464722 hasConcept C2775905019 @default.
• W2997464722 hasConcept C2777752497 @default.
• W2997464722 hasConcept C2781182431 @default.
• W2997464722 hasConcept C2993283237 @default.
• W2997464722 hasConcept C54355233 @default.
• W2997464722 hasConcept C55493867 @default.
• W2997464722 hasConcept C71240020 @default.
• W2997464722 hasConcept C71924100 @default.
• W2997464722 hasConcept C81885089 @default.
• W2997464722 hasConcept C86803240 @default.
• W2997464722 hasConceptScore W2997464722C104317684 @default.
• W2997464722 hasConceptScore W2997464722C109316439 @default.
• W2997464722 hasConceptScore W2997464722C121608353 @default.
• W2997464722 hasConceptScore W2997464722C126322002 @default.
• W2997464722 hasConceptScore W2997464722C133571119 @default.
• W2997464722 hasConceptScore W2997464722C169760540 @default.
• W2997464722 hasConceptScore W2997464722C17077164 @default.
• W2997464722 hasConceptScore W2997464722C185592680 @default.
• W2997464722 hasConceptScore W2997464722C19549132 @default.
• W2997464722 hasConceptScore W2997464722C202751555 @default.
• W2997464722 hasConceptScore W2997464722C206103511 @default.
• W2997464722 hasConceptScore W2997464722C25170562 @default.
• W2997464722 hasConceptScore W2997464722C2775905019 @default.
• W2997464722 hasConceptScore W2997464722C2777752497 @default.
• W2997464722 hasConceptScore W2997464722C2781182431 @default.
• W2997464722 hasConceptScore W2997464722C2993283237 @default.
• W2997464722 hasConceptScore W2997464722C54355233 @default.
• W2997464722 hasConceptScore W2997464722C55493867 @default.
• W2997464722 hasConceptScore W2997464722C71240020 @default.
• W2997464722 hasConceptScore W2997464722C71924100 @default.
• W2997464722 hasConceptScore W2997464722C81885089 @default.
• W2997464722 hasConceptScore W2997464722C86803240 @default.
• W2997464722 hasFunder F4320321001 @default.
• W2997464722 hasLocation W29974647221 @default.
• W2997464722 hasOpenAccess W2997464722 @default.
• W2997464722 hasPrimaryLocation W29974647221 @default.

• next