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- W2997468354 abstract "Organometallic catalysts are useful in lab research, and some are used industrially. They generally don’t work well in living cells. But researchers have now assembled an artificial enzyme with an organometallic active site in bacteria and coaxed it to catalyze an industrially relevant reaction that has never occurred before in live cells. They also used directed evolution, a lab mimic of natural evolution, to optimize and customize the catalyst in vivo. The work could lead to the use of living cells as molecular factories to produce high-value chemical products they would not normally make. Thomas Ward of the University of Basel, Sven Panke of the Swiss Federal Institute of Technology, Zurich, and coworkers carried out the study (Nature 2016, DOI: 10.1038/nature19114). The team’s aim was to create a synthetic metalloenzyme that could catalyze olefin metathesis—a Nobel Prize-honored reaction that rearranges carbon-carbon double bonds—in living cells. To accomplish this, the researchers" @default.
- W2997468354 created "2020-01-10" @default.
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- W2997468354 date "2016-09-05" @default.
- W2997468354 modified "2023-10-16" @default.
- W2997468354 title "Organometallic reaction runs in living cells" @default.
- W2997468354 doi "https://doi.org/10.1021/cen-09435-notw7" @default.
- W2997468354 hasPublicationYear "2016" @default.
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