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- W2997471364 endingPage "1324" @default.
- W2997471364 startingPage "1315" @default.
- W2997471364 abstract "MicroRNA-183(miR-183) is abnormally expressed in many kinds of tumors. It participates in the initiation and development of tumors. There are many pathways regulate the expression of miR-183. The action mechanism of miR-183 in cancer is very extensive, and contradictory conclusions are often drawn. It was upregulated in 18 kinds of cancer, downregulated in 6 kinds of cancer. In addition, there are seven types of cancer, both upregulated and downregulated reports can be found. Evidence showed that miR-183 can not only directly play the role of oncogene or antioncogene, but also regulate the expression of other oncogene or antioncogene in different cancer types. In this review, we discuss the regulator of miR-183 and summarized the expression of miR-183 in different cancers. We also counted the target genes of miR-183 and the functional roles they play. Furthermore, we focused on the roles of miR-183 in cell migration, cell invasion, epithelial-mesenchymal transition (EMT) and microangiogenesis, which play the most important roles in cancer processes. It sheds light on the likely reasons why miR-183 plays different roles in various cancers. In addition, miR-183 and its downstream effectors have the potential to be promising prognostic markers and therapeutic targets in cancer." @default.
- W2997471364 created "2020-01-10" @default.
- W2997471364 creator A5012022838 @default.
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- W2997471364 creator A5031013186 @default.
- W2997471364 creator A5044740077 @default.
- W2997471364 creator A5084982362 @default.
- W2997471364 creator A5091271775 @default.
- W2997471364 date "2020-01-01" @default.
- W2997471364 modified "2023-10-01" @default.
- W2997471364 title "MicroRNA-183 in Cancer Progression" @default.
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