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• W2997473543 endingPage "102154" @default.
• W2997473543 startingPage "102154" @default.
• W2997473543 abstract "As a solute carrier electrogenic transporter, the sodium/calcium exchanger (NCX1-3/SLC8A1-A3) links the trans-plasmalemmal gradients of sodium and calcium ions (Na+, Ca2+) to the membrane potential of astrocytes. Classically, NCX is considered to serve the export of Ca2+ at the expense of the Na+ gradient, defined as a forward operation. Forward mode NCX activity contributes to Ca2+ extrusion and thus to the recovery from intracellular Ca2+ signals in astrocytes. The reversal potential of the NCX, owing to its transport stoichiometry of 3 Na+ to 1 Ca2+, is, however, close to the astrocytes' membrane potential and hence even small elevations in the astrocytic Na+ concentration or minor depolarisations switch it into the (Ca2+ import/Na+ export). Notably, transient Na+ elevations in the millimolar range are induced by uptake of glutamate or GABA into astrocytes and/or by the opening of Na+-permeable ion channels in response to neuronal activity. Activity-related Na+ transients result in NCX reversal, which mediates Ca2+ influx from the extracellular space, thereby generating astrocyte Ca2+ signalling independent from InsP3-mediated release from intracellular stores. Under pathological conditions, reverse NCX promotes cytosolic Ca2+ overload, while dampening Na+ elevations of astrocytes. This review provides an overview on our current knowledge about this fascinating transporter and its special functional role in astrocytes. We shall delineate that Na+-driven, reverse NCX-mediated astrocyte Ca2+ signals are involved neurone-glia interaction. Na+ transients, translated by the NCX into Ca2+ elevations, thereby emerge as a new signalling pathway in astrocytes." @default.
• W2997473543 created "2020-01-10" @default.
• W2997473543 creator A5004662891 @default.
• W2997473543 creator A5083227570 @default.
• W2997473543 creator A5090508856 @default.
• W2997473543 date "2020-03-01" @default.
• W2997473543 modified "2023-10-17" @default.
• W2997473543 title "On the special role of NCX in astrocytes: Translating Na+-transients into intracellular Ca2+ signals" @default.
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