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- W2997504214 abstract "Background/Aim: The chromosome translocation t(14;21)(q11;q22) was reported in four pediatric T-cell lymphoblastic leukemias and was shown to activate the OLIG2 gene. Materials and Methods: A pediatric T-cell lymphoblastic lymphoma was investigated using G-banding chromosome analysis, fluorescence in situ hybridization (FISH), and immunocytochemistry. Results: The malignant cells carried a t(14;21)(q11;q22) aberration. The translocation moves the enhancer elements of TRA/TRD from band 14q11 to 21q22, a few thousands kbp downstream of OLIG1 and OLIG2, resulting in the production of both OLIG1 and OLIG2 proteins. Conclusion: The translocation t(14;21)(q11;q22) occurs in some pediatric T-cell lymphoblastic malignancies. Activation of both OLIG1 and OLIG2 by t(14;21)(q11;q22) in T-lymphoblasts and the ensuing deregulation of thousands of genes could explain the highly malignant disease and resistance to treatment that has characterized this small group of patients." @default.
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- W2997504214 date "2019-12-27" @default.
- W2997504214 modified "2023-10-01" @default.
- W2997504214 title "Chromosome Translocation t(14;21)(q11;q22) Activates Both <i>OLIG1</i> and <i>OLIG2</i> in Pediatric T-cell Lymphoblastic Malignancies and May Signify Adverse Prognosis" @default.
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- W2997504214 doi "https://doi.org/10.21873/cgp.20166" @default.
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