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• W2997520568 abstract "Abstract Water soluble sodium 4‐amino‐5‐hydroxy‐7‐sulfonaphthalene‐2‐sulfonate ligand was used successfully for the preparation of 1,2,3‐triazoles pharmacophore linked‐quinazolinone scaffold. The reaction of ethyl 4‐oxo‐3,4‐dihydroquinazoline‐2‐carboxylate and related amide compounds with propargyl bromide afforded ethyl 4‐oxo‐3‐(prop‐2‐yn‐1‐yl)‐3,4‐dihydroquinazoline‐2‐carboxylate and its amide derivatives. The reaction of propargylated compounds with azides catalyzed by copper (II) salt, in the presence of Sodium 4‐amino‐5‐hydroxy‐7‐sulfonaphthalene‐2‐sulfonate as a ligand in water produced novel 1,2,3‐triazole pharmacophore linked‐quinazolinone‐4‐one scaffold with high‐to‐excellent yields. The ligand assisted in the click reaction and reduced loading of copper salt to 2 mol%. Simplicity, short reaction times, use of water as green solvent, and low catalyst loading are the main advantages of this procedure." @default.
• W2997520568 created "2020-01-10" @default.
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• W2997520568 creator A5008617777 @default.
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• W2997520568 date "2019-12-30" @default.
• W2997520568 modified "2023-09-28" @default.
• W2997520568 title "Sodium 4‐amino‐5‐hydroxy‐7‐sulfonaphthalene‐2‐sulfonate an efficient ligand for click reaction in water: Synthesis of 1,2,3‐triazole pharmacophore linked‐quinazolinone scaffold" @default.
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• W2997520568 doi "https://doi.org/10.1002/jhet.3832" @default.
• W2997520568 hasPublicationYear "2019" @default.
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