FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997629230> ?p ?o ?g. }

• W2997629230 endingPage "158608" @default.
• W2997629230 startingPage "158608" @default.
• W2997629230 abstract "Brain-specific diacylglycerol kinase (DGK) δ-knockout mice exhibited serotonin transporter (SERT) inhibitor-sensitive obsessive-compulsive disorder-like behaviors. Moreover, SERT protein levels were markedly increased in the DGKδ-deficient brain. However, its molecular mechanisms remain unclear. We found that the catalytic subdomain-a and the coiled-coil structure-containing region of DGKδ interacted with the C-terminal cytoplasmic region (CTC) of SERT. Moreover, the protein levels of full-length SERT and SERT-CTC alone were significantly decreased by DGKδ in a catalytic activity-dependent manner. A proteasome inhibitor, MG-132, inhibited DGKδ-dependent SERT degradation. Notably, DGKδ interacted with MAGE-D1 adaptor protein and Praja-1 E3 ubiquitin-protein ligase, and enhanced the ubiquitination of SERT through Praja-1. Taken together, these results indicate that DGKδ interacts with SERT and induces SERT degradation in an activity-dependent manner through the Praja-1 ubiquitin ligase-proteasome system. These new findings provide novel insights into serotonergic system regulation and the pathophysiology/therapeutics of serotonin-/SERT-related diseases such as obsessive-compulsive disorder, depression, autism and schizophrenia." @default.
• W2997629230 created "2020-01-10" @default.
• W2997629230 creator A5018843945 @default.
• W2997629230 creator A5052438029 @default.
• W2997629230 creator A5069450738 @default.
• W2997629230 creator A5084587045 @default.
• W2997629230 creator A5085003537 @default.
• W2997629230 date "2020-03-01" @default.
• W2997629230 modified "2023-10-14" @default.
• W2997629230 title "Diacylglycerol kinase δ destabilizes serotonin transporter protein through the ubiquitin-proteasome system" @default.
• W2997629230 cites W1828538530 @default.
• W2997629230 cites W1911240071 @default.
• W2997629230 cites W1968540273 @default.
• W2997629230 cites W1969893193 @default.
• W2997629230 cites W1972408555 @default.
• W2997629230 cites W1977068073 @default.
• W2997629230 cites W1980151609 @default.
• W2997629230 cites W1988865934 @default.
• W2997629230 cites W1991156457 @default.
• W2997629230 cites W1992547494 @default.
• W2997629230 cites W1995763262 @default.
• W2997629230 cites W2002183064 @default.
• W2997629230 cites W2013706577 @default.
• W2997629230 cites W2018764383 @default.
• W2997629230 cites W2018913954 @default.
• W2997629230 cites W2027164618 @default.
• W2997629230 cites W2030242161 @default.
• W2997629230 cites W2034430975 @default.
• W2997629230 cites W2037167271 @default.
• W2997629230 cites W2044626994 @default.
• W2997629230 cites W2046518480 @default.
• W2997629230 cites W2056801079 @default.
• W2997629230 cites W2058715179 @default.
• W2997629230 cites W2059574576 @default.
• W2997629230 cites W2065963618 @default.
• W2997629230 cites W2075557883 @default.
• W2997629230 cites W2082226431 @default.
• W2997629230 cites W2084516040 @default.
• W2997629230 cites W2089603635 @default.
• W2997629230 cites W2095213614 @default.
• W2997629230 cites W2123003348 @default.
• W2997629230 cites W2124333083 @default.
• W2997629230 cites W2155060440 @default.
• W2997629230 cites W2166817392 @default.
• W2997629230 cites W2170165316 @default.
• W2997629230 cites W2181778583 @default.
• W2997629230 cites W2461823623 @default.
• W2997629230 cites W2522621982 @default.
• W2997629230 cites W2595007275 @default.
• W2997629230 cites W2794191069 @default.
• W2997629230 cites W2986552701 @default.
• W2997629230 doi "https://doi.org/10.1016/j.bbalip.2019.158608" @default.
• W2997629230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31891772" @default.
• W2997629230 hasPublicationYear "2020" @default.
• W2997629230 type Work @default.
• W2997629230 sameAs 2997629230 @default.
• W2997629230 citedByCount "12" @default.
• W2997629230 countsByYear W29976292302020 @default.
• W2997629230 countsByYear W29976292302021 @default.
• W2997629230 countsByYear W29976292302022 @default.
• W2997629230 countsByYear W29976292302023 @default.
• W2997629230 crossrefType "journal-article" @default.
• W2997629230 hasAuthorship W2997629230A5018843945 @default.
• W2997629230 hasAuthorship W2997629230A5052438029 @default.
• W2997629230 hasAuthorship W2997629230A5069450738 @default.
• W2997629230 hasAuthorship W2997629230A5084587045 @default.
• W2997629230 hasAuthorship W2997629230A5085003537 @default.
• W2997629230 hasConcept C104317684 @default.
• W2997629230 hasConcept C126322002 @default.
• W2997629230 hasConcept C134018914 @default.
• W2997629230 hasConcept C134459356 @default.
• W2997629230 hasConcept C170493617 @default.
• W2997629230 hasConcept C184235292 @default.
• W2997629230 hasConcept C185592680 @default.
• W2997629230 hasConcept C195794163 @default.
• W2997629230 hasConcept C25602115 @default.
• W2997629230 hasConcept C27740335 @default.
• W2997629230 hasConcept C2775864247 @default.
• W2997629230 hasConcept C2778897192 @default.
• W2997629230 hasConcept C36020004 @default.
• W2997629230 hasConcept C37000724 @default.
• W2997629230 hasConcept C55493867 @default.
• W2997629230 hasConcept C71924100 @default.
• W2997629230 hasConcept C86803240 @default.
• W2997629230 hasConcept C95444343 @default.
• W2997629230 hasConceptScore W2997629230C104317684 @default.
• W2997629230 hasConceptScore W2997629230C126322002 @default.
• W2997629230 hasConceptScore W2997629230C134018914 @default.
• W2997629230 hasConceptScore W2997629230C134459356 @default.
• W2997629230 hasConceptScore W2997629230C170493617 @default.
• W2997629230 hasConceptScore W2997629230C184235292 @default.
• W2997629230 hasConceptScore W2997629230C185592680 @default.
• W2997629230 hasConceptScore W2997629230C195794163 @default.
• W2997629230 hasConceptScore W2997629230C25602115 @default.
• W2997629230 hasConceptScore W2997629230C27740335 @default.
• W2997629230 hasConceptScore W2997629230C2775864247 @default.
• W2997629230 hasConceptScore W2997629230C2778897192 @default.
• W2997629230 hasConceptScore W2997629230C36020004 @default.

• next