Matches in SemOpenAlex for { <https://semopenalex.org/work/W2997641418> ?p ?o ?g. }
Showing items 1 to 50 of
50
with 100 items per page.
- W2997641418 abstract "9558 Background: Due to challenges in the delivery of pediatric oncology care in low-middle income countries (LMIC), diagnosis and treatment remains inadequate for the majority of patients. The University of Zambia School of Medicine/University Teaching Hospital (UTH) and Vanderbilt University School of Medicine/Vanderbilt Institute for Global Health established a partnership to investigate treatment outcomes at UTH, the only institution providing pediatric oncology care in Zambia, and assess risk factors associated with treatment abandonment. Methods: A retrospective study was conducted in a cohort of patients, presenting from July 2008 – June 2010, using an established database and medical record review. Results: Of the 230 children enrolled in the database, 162 met the inclusion criteria. The average age at diagnosis was 6.0 years; males comprised 55.6% of the cohort; 51.6% had a histopathological diagnosis and 10.5% of the cohort was HIV positive. The most common diagnoses were lymphoma (25.9%), Wilms tumor (22.8%), and retinoblastoma (17.9%). Leukemia and Kaposi sarcoma accounted for 7.4% each. Death (46.3%) and abandonment of treatment (45.7%) were the most common outcomes with only 8.0% having completed treatment or currently undergoing treatment, including palliative regimens, at the time of data acquisition. Residence in Lusaka or Central provinces, closest in proximity to UTH, was associated with a decreased risk for abandonment of treatment (Odds Ratio (OR) 0.41 (95% CI 0.21-0.81, p = 0.009) while maternal education less than secondary school (OR 2.73 95% CI 1.2-6.6, p = 0.03) was associated with an increased risk for abandonment of treatment. Conclusions: At the only pediatric cancer center in Zambia, treatment outcomes are dire with the majority of the cohort abandoning treatment or dying during therapy. Challenges include access to cancer chemotherapy, logistical facilitation, fiscal support of radiotherapy, and community engagement. Further investigation is required to inform effective intervention strategies to improve outcomes." @default.
- W2997641418 created "2020-01-10" @default.
- W2997641418 creator A5000787942 @default.
- W2997641418 creator A5020344819 @default.
- W2997641418 creator A5029125087 @default.
- W2997641418 creator A5039928708 @default.
- W2997641418 creator A5041134007 @default.
- W2997641418 creator A5041729974 @default.
- W2997641418 creator A5066699228 @default.
- W2997641418 creator A5073473981 @default.
- W2997641418 creator A5073643979 @default.
- W2997641418 creator A5083164199 @default.
- W2997641418 creator A5089511558 @default.
- W2997641418 date "2012-05-20" @default.
- W2997641418 modified "2023-09-26" @default.
- W2997641418 title "Treatment outcomes of pediatric oncology patients in Zambia." @default.
- W2997641418 doi "https://doi.org/10.1200/jco.2012.30.15_suppl.9558" @default.
- W2997641418 hasPublicationYear "2012" @default.
- W2997641418 type Work @default.
- W2997641418 sameAs 2997641418 @default.
- W2997641418 citedByCount "0" @default.
- W2997641418 crossrefType "journal-article" @default.
- W2997641418 hasAuthorship W2997641418A5000787942 @default.
- W2997641418 hasAuthorship W2997641418A5020344819 @default.
- W2997641418 hasAuthorship W2997641418A5029125087 @default.
- W2997641418 hasAuthorship W2997641418A5039928708 @default.
- W2997641418 hasAuthorship W2997641418A5041134007 @default.
- W2997641418 hasAuthorship W2997641418A5041729974 @default.
- W2997641418 hasAuthorship W2997641418A5066699228 @default.
- W2997641418 hasAuthorship W2997641418A5073473981 @default.
- W2997641418 hasAuthorship W2997641418A5073643979 @default.
- W2997641418 hasAuthorship W2997641418A5083164199 @default.
- W2997641418 hasAuthorship W2997641418A5089511558 @default.
- W2997641418 hasConcept C121608353 @default.
- W2997641418 hasConcept C126322002 @default.
- W2997641418 hasConcept C143998085 @default.
- W2997641418 hasConcept C2909143077 @default.
- W2997641418 hasConcept C71924100 @default.
- W2997641418 hasConceptScore W2997641418C121608353 @default.
- W2997641418 hasConceptScore W2997641418C126322002 @default.
- W2997641418 hasConceptScore W2997641418C143998085 @default.
- W2997641418 hasConceptScore W2997641418C2909143077 @default.
- W2997641418 hasConceptScore W2997641418C71924100 @default.
- W2997641418 hasLocation W29976414181 @default.
- W2997641418 hasOpenAccess W2997641418 @default.
- W2997641418 hasPrimaryLocation W29976414181 @default.
- W2997641418 isParatext "false" @default.
- W2997641418 isRetracted "false" @default.
- W2997641418 magId "2997641418" @default.
- W2997641418 workType "article" @default.