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- W2997644807 abstract "Hurthle cells (HC) and HC neoplasms attract attention of scientists, but some aspects are still controversial. Objective — to analyze modern literature data considering HC and toreveal the prevalence of oncocytic transformation of thyrocytes and distribution of its types in Subcarpathian endemic goiter region. Materials and methods. We held a data search in Pubmed database and studied the revealed references. We also analyzed the results of pathohistological investigation of surgical material of 1233 patients who underwent surgery because of thyroid gland (TG) diseases. Results and discussion. HC were for the first time described by Max Ashkenasi in1898, but mistakenly called after Carl Hurthle. The main characteristics of HC include large number of mitochondria, clear borders, round shape, loss of cellular polarity, large hyperchromatic round nucleus, its variable atypia, distinct nucleolus. Transformation of thyrocytes into oncocytes can accompany both benign and malignant processes, and also non-neoplasmatic diseases. All HC neoplasms, which are not definitely benign, must undergo surgical resection for final diagnosis. TG can form both HC adenomas (HCA) and carcinomas (HCC). The majority of analyzed patients were female (82.6 %). Oncocytic transformation of thyrocytes was revealed in 71 case (5.8 %). 50.7 % cases of oncocytic transformation were represented by HC clusters, 25.4 % — by oncocytic nodules. In males oncocytic transformation the most often was represented by HCA (40 %), in females — by HC clusters (57.4 %). Conclusions. HС have finely defined characteristics and can accompany both benign and malignant conditions. Oncocytic transformation was revealed in 5.8 % of patients; more often in women than in men. Oncocytic transformation of thyrocytes can be represented by HC clusters, hyperplastic nodules, HCA and HCC. HC clusters are the most typical type in women, HCA — in men. Frequency of HCC in men was higher than in women." @default.
- W2997644807 created "2020-01-10" @default.
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- W2997644807 date "2019-12-24" @default.
- W2997644807 modified "2023-09-25" @default.
- W2997644807 title "Hurtle-cell carcinoma of thyroid gland: literature review and own data" @default.
- W2997644807 doi "https://doi.org/10.30978/cees-2019-4-7" @default.
- W2997644807 hasPublicationYear "2019" @default.
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