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- W2997647369 abstract "Many studies showed an important role of inflammation in heart failure (HF). Monocytes/macrophages are main cells take part in immune response. The purpose of study was to investigate spontaneous cytokines production by monocytes/macrophages in patient with chronic heart failure of ischemic origin. Materials and Methods: 96 patients with HF of ischemic genesis were observed. The spontaneous production of interleukin 1b (IL-1b), interleukin 6 (IL-6), and interleukin 10 (IL-10) by monocytes/macrophages in vitro was detected by ELISA method.Results: The in vitro spontaneous production of proinflammatory cytokines IL-1b and IL-6 by monocytes/macrophages in patients with HF was significant higher and anti-inflammatory IL-10 was lower than in control group. The progression of HF caused to increase of spontaneous production by monocytes/macrophages of IL-1b and IL-6 but decrease of IL-10.Conclusion: The monocytes/macrophages in patients with ischemic HF are in condition of chronic activation which manifests of overproduction of proinflammatory cytokines and poor secretion of anti-inflammatory IL-10." @default.
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- W2997647369 date "2019-12-01" @default.
- W2997647369 modified "2023-09-28" @default.
- W2997647369 title "in vitro production of cytokines by monocytes/macrophages in patients with chronic heart failure" @default.
- W2997647369 hasPublicationYear "2019" @default.
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