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- W2997656487 abstract "Background: Chemotherapy is increasingly used prior to resection of colorectal liver metastases. We assessed the capacity of 99mTc-labelled-mebrofenin SPECT-hepatobiliary scintigraphy (HBS) to predict chemotherapy-associated liver injuries (CALI). In parallel, we analyzed the hepatocyte isolation outcome to elucidate the mechanisms of alteration of liver function. Methods: From 2011 to 2015, 115 noncirrhotic patients undergoing hepatectomy gave informed consent for preoperative HBS (NCT 02753517), allowing measurements of intrinsic liver function. In parallel, since 2006 hepatocytes viability and yield were analyzed via liver tissues obtained from 164 fully-consenting patients undergoing hepatectomy. Patients were compared according to neoadjuvant chemotherapy and CALI, mainly sinusoidal obstruction syndrome (SOS) and non-alcoholic steatohepatitis activity score (NAS). Results: In 115 patients, 40% had neoadjuvant chemotherapy and 96% a major hepatectomy. Overall, neoadjuvant chemotherapy had no impact on liver function (except when ≥12 cures), nor hepatocytes isolation. Regarding CALI, NAS significantly impaired the FRL function, cell viability and yield for NAS 2-5, whereas SOS had no impact. Chemotherapy-treated patients with marked SOS and/or NAS (≥2) showed higher rates of morbi-mortality. Conclusion: Neoadjuvant chemotherapy affected directly hepatocytes in case of NAS with subsequently-impaired liver function, in contrast to SOS involving mainly non-hepatocellular cells with deleterious portal hypertension." @default.
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- W2997656487 date "2019-01-01" @default.
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- W2997656487 title "Impact of modern chemotherapy before hepatectomy – assessment of hepatocytes function and viability via SPECT-scintigraphy and hepatocytes isolation" @default.
- W2997656487 doi "https://doi.org/10.1016/j.hpb.2019.10.237" @default.
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