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- W2997658354 abstract "Macrophages are central to inflammation resolution, an active process aimed at restoring tissue homeostasis following an inflammatory response. Here, the effects of db-cAMP on macrophage phenotype and function were investigated. Injection of db-cAMP into the pleural cavity of mice induced monocytes recruitment in a manner dependent on PKA and CCR2/CCL2 pathways. Furthermore, db-cAMP promoted reprogramming of bone-marrow-derived macrophages to a M2 phenotype as seen by increased Arg-1/CD206/Ym-1 expression and IL-10 levels (M2 markers). Db-cAMP also showed a synergistic effect with IL-4 in inducing STAT-3 phosphorylation and Arg-1 expression. Importantly, db-cAMP prevented IFN-γ/LPS-induced macrophage polarization to M1-like as shown by increased Arg-1 associated to lower levels of M1 cytokines (TNF-α/IL-6) and p-STAT1. In vivo, db-cAMP reduced the number of M1 macrophages induced by LPS injection without changes in M2 and Mres numbers. Moreover, db-cAMP enhanced efferocytosis of apoptotic neutrophils in a PKA-dependent manner and increased the expression of Annexin A1 and CD36, two molecules associated with efferocytosis. Finally, inhibition of endogenous PKA during LPS-induced pleurisy impaired the physiological resolution of inflammation. Taken together, the results suggest that cAMP is involved in the major functions of macrophages, such as nonphlogistic recruitment, reprogramming and efferocytosis, all key processes for inflammation resolution." @default.
- W2997658354 created "2020-01-10" @default.
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- W2997658354 date "2020-01-06" @default.
- W2997658354 modified "2023-10-15" @default.
- W2997658354 title "Cyclic AMP Regulates Key Features of Macrophages via PKA: Recruitment, Reprogramming and Efferocytosis" @default.
- W2997658354 cites W1573103899 @default.
- W2997658354 cites W1578893636 @default.
- W2997658354 cites W1585536154 @default.
- W2997658354 cites W1592393293 @default.
- W2997658354 cites W1610351097 @default.
- W2997658354 cites W1771162562 @default.
- W2997658354 cites W1836416096 @default.
- W2997658354 cites W1874935363 @default.
- W2997658354 cites W1910505291 @default.
- W2997658354 cites W1955937578 @default.
- W2997658354 cites W1966518454 @default.
- W2997658354 cites W1969039812 @default.
- W2997658354 cites W1971716848 @default.
- W2997658354 cites W1981206299 @default.
- W2997658354 cites W1982292637 @default.
- W2997658354 cites W1982727668 @default.
- W2997658354 cites W1983072435 @default.
- W2997658354 cites W1984079217 @default.
- W2997658354 cites W1984554579 @default.
- W2997658354 cites W1985855344 @default.
- W2997658354 cites W1986480779 @default.
- W2997658354 cites W1986668505 @default.
- W2997658354 cites W1988342604 @default.
- W2997658354 cites W1989201814 @default.
- W2997658354 cites W1991047945 @default.
- W2997658354 cites W2008186393 @default.
- W2997658354 cites W2014648507 @default.
- W2997658354 cites W2017215076 @default.
- W2997658354 cites W2018971079 @default.
- W2997658354 cites W2023800097 @default.
- W2997658354 cites W2027042060 @default.
- W2997658354 cites W2030368378 @default.
- W2997658354 cites W2032234779 @default.
- W2997658354 cites W2033861402 @default.
- W2997658354 cites W2036852690 @default.
- W2997658354 cites W2037697142 @default.
- W2997658354 cites W2043981736 @default.
- W2997658354 cites W2055724614 @default.
- W2997658354 cites W2065210647 @default.
- W2997658354 cites W2065769697 @default.
- W2997658354 cites W2065892131 @default.
- W2997658354 cites W2066000649 @default.
- W2997658354 cites W2071746261 @default.
- W2997658354 cites W2079331198 @default.
- W2997658354 cites W2081179849 @default.
- W2997658354 cites W2093705034 @default.
- W2997658354 cites W2095537212 @default.
- W2997658354 cites W2103943909 @default.
- W2997658354 cites W2108426267 @default.
- W2997658354 cites W2111718223 @default.
- W2997658354 cites W2112280022 @default.
- W2997658354 cites W2112842079 @default.
- W2997658354 cites W2118189387 @default.
- W2997658354 cites W2120111127 @default.
- W2997658354 cites W2120699390 @default.
- W2997658354 cites W2123406821 @default.
- W2997658354 cites W2124141025 @default.
- W2997658354 cites W2128611559 @default.
- W2997658354 cites W2131778644 @default.
- W2997658354 cites W2134101952 @default.
- W2997658354 cites W2135703618 @default.
- W2997658354 cites W2140380746 @default.
- W2997658354 cites W2141134562 @default.
- W2997658354 cites W2142361972 @default.
- W2997658354 cites W2148056149 @default.
- W2997658354 cites W2149254293 @default.
- W2997658354 cites W2150334056 @default.
- W2997658354 cites W2158356938 @default.
- W2997658354 cites W2159560463 @default.
- W2997658354 cites W2162462917 @default.
- W2997658354 cites W2163175900 @default.
- W2997658354 cites W2165892104 @default.
- W2997658354 cites W2166495235 @default.
- W2997658354 cites W2168897708 @default.
- W2997658354 cites W2169735431 @default.
- W2997658354 cites W2196088104 @default.
- W2997658354 cites W2201819417 @default.
- W2997658354 cites W2210741139 @default.
- W2997658354 cites W2273234143 @default.
- W2997658354 cites W2279007355 @default.
- W2997658354 cites W2297931714 @default.
- W2997658354 cites W2329012680 @default.